HCSGD entry for PSMD14

1. General information

Official gene symbolPSMD14
Entrez ID10213
Gene full nameproteasome (prosome, macropain) 26S subunit, non-ATPase, 14
Other gene symbolsPAD1 POH1 RPN11
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0000209Protein polyubiquitinationTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0000502Proteasome complexTAScellular_component
GO:0000724Double-strand break repair via homologous recombinationIMPbiological_process
GO:0002474Antigen processing and presentation of peptide antigen via MHC class ITASbiological_process
GO:0002479Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTASbiological_process
GO:0004221Ubiquitin thiolesterase activityIMP TASmolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0006303Double-strand break repair via nonhomologous end joiningIMPbiological_process
GO:0006511Ubiquitin-dependent protein catabolic processTASbiological_process
GO:0006521Regulation of cellular amino acid metabolic processTASbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestTASbiological_process
GO:0008237Metallopeptidase activityTASmolecular_function
GO:0008541Proteasome regulatory particle, lid subcomplexIMPcellular_component
GO:0010467Gene expressionTASbiological_process
GO:0010950Positive regulation of endopeptidase activityIMPbiological_process
GO:0010952Positive regulation of peptidase activityIMPbiological_process
GO:0016032Viral processTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0022624Proteasome accessory complexIEA ISScellular_component
GO:0031145Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processTASbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0042981Regulation of apoptotic processTASbiological_process
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0051436Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051437Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051439Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0052547Regulation of peptidase activityIMPbiological_process
GO:0052548Regulation of endopeptidase activityIMPbiological_process
GO:0061133Endopeptidase activator activityIMPmolecular_function
GO:0061136Regulation of proteasomal protein catabolic processIMPbiological_process
GO:0070536Protein K63-linked deubiquitinationIMP TASbiological_process
GO:0070628Proteasome bindingIDAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.09805479660.75085706850.65372348021.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.5029451683
GSE13712_SHEARUp0.2152913066
GSE13712_STATICUp0.2087161631
GSE19018Down-0.1569615132
GSE19899_A1Up0.4157275394
GSE19899_A2Up0.1803135535
PubMed_21979375_A1Up0.8047036870
PubMed_21979375_A2Up0.1374513379
GSE35957Down-0.1998243303
GSE36640Down-0.0476856671
GSE54402Up0.4394651422
GSE9593Down-0.0265212433
GSE43922Up0.1348116036
GSE24585Down-0.0986040777
GSE37065Down-0.0151633441
GSE28863_A1Down-0.2369328774
GSE28863_A2Up0.6016170213
GSE28863_A3Down-0.3633875637
GSE28863_A4Down-0.1066643650
GSE48662Down-0.5616894781

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-23b-3pMIMAT0000418MIRT046307CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22473755Importantly, two 19S subunits, Rpn7 and Rpn11, colocalize with DNA damage foci over their whole lifespan
22473755Although silencing of Rpn11 does not affect foci stability and lifespan, silencing of Rpn7 promotes faster resolution of DNA damage foci following genotoxic insult
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