HCSGD entry for ADAM10
1. General information
| Official gene symbol | ADAM10 |
|---|---|
| Entrez ID | 102 |
| Gene full name | ADAM metallopeptidase domain 10 |
| Other gene symbols | AD10 CD156c HsT18717 MADM kuz |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001701 | In utero embryonic development | ISS | biological_process |
| GO:0004175 | Endopeptidase activity | ISS | molecular_function |
| GO:0004222 | Metalloendopeptidase activity | IEA IMP NAS | molecular_function |
| GO:0005102 | Receptor binding | NAS | molecular_function |
| GO:0005178 | Integrin binding | NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | ISS | cellular_component |
| GO:0005737 | Cytoplasm | ISS | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005798 | Golgi-associated vesicle | IDA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006468 | Protein phosphorylation | ISS | biological_process |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0006509 | Membrane protein ectodomain proteolysis | IDA IEA IMP | biological_process |
| GO:0007162 | Negative regulation of cell adhesion | IDA NAS | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007219 | Notch signaling pathway | IEA ISS TAS | biological_process |
| GO:0007220 | Notch receptor processing | TAS | biological_process |
| GO:0007229 | Integrin-mediated signaling pathway | IEA NAS | biological_process |
| GO:0007267 | Cell-cell signaling | NAS | biological_process |
| GO:0008237 | Metallopeptidase activity | IDA IEA IMP TAS | molecular_function |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0008284 | Positive regulation of cell proliferation | IMP | biological_process |
| GO:0009986 | Cell surface | IDA | cellular_component |
| GO:0010820 | Positive regulation of T cell chemotaxis | IMP | biological_process |
| GO:0012505 | Endomembrane system | IEA | cellular_component |
| GO:0014069 | Postsynaptic density | IEA | cellular_component |
| GO:0016021 | Integral component of membrane | NAS | cellular_component |
| GO:0017124 | SH3 domain binding | IEA | molecular_function |
| GO:0019901 | Protein kinase binding | ISS | molecular_function |
| GO:0022617 | Extracellular matrix disassembly | TAS | biological_process |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0030307 | Positive regulation of cell growth | IMP | biological_process |
| GO:0030335 | Positive regulation of cell migration | IMP | biological_process |
| GO:0030574 | Collagen catabolic process | TAS | biological_process |
| GO:0034612 | Response to tumor necrosis factor | IDA | biological_process |
| GO:0042117 | Monocyte activation | IMP | biological_process |
| GO:0042803 | Protein homodimerization activity | ISS | molecular_function |
| GO:0051088 | PMA-inducible membrane protein ectodomain proteolysis | IMP | biological_process |
| GO:0051089 | Constitutive protein ectodomain proteolysis | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1068514760 | 0.0379410585 | 0.6794300266 | 0.3671053250 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.6180100921 |
| GSE13712_SHEAR | Down | -0.3357015796 |
| GSE13712_STATIC | Down | -0.1867960914 |
| GSE19018 | Up | 0.4679229354 |
| GSE19899_A1 | Down | -1.2884188950 |
| GSE19899_A2 | Down | -0.4784633522 |
| PubMed_21979375_A1 | Down | -1.3426408401 |
| PubMed_21979375_A2 | Down | -0.7324929936 |
| GSE35957 | Up | 0.7370138690 |
| GSE36640 | Up | 0.2394977176 |
| GSE54402 | Down | -0.7659739727 |
| GSE9593 | Up | 0.3851968968 |
| GSE43922 | Down | -0.3019625773 |
| GSE24585 | Up | 0.4329438914 |
| GSE37065 | Up | 0.2376243953 |
| GSE28863_A1 | Up | 0.9953682794 |
| GSE28863_A2 | Up | 0.7312395396 |
| GSE28863_A3 | Down | -0.2729956792 |
| GSE28863_A4 | Up | 0.1840160520 |
| GSE48662 | Up | 0.0821691826 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| XL784 | DB04991 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-122-5p | MIMAT0000421 | MIRT004879 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 19726678 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT021045 | Proteomics | Functional MTI (Weak) | 21030878 |
| hsa-miR-484 | MIMAT0002174 | MIRT041888 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 16303768 | ADAM10 (a disintegrin and metalloprotease 10) and BACE (beta-site APP-cleaving enzyme) protein levels exhibited no age-associated regulation, but interestingly, BACE enzymatic activity was increased in aged cells |
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