HCSGD entry for PSME3

1. General information

Official gene symbolPSME3
Entrez ID10197
Gene full nameproteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
Other gene symbolsKi PA28-gamma PA28G PA28gamma REG-GAMMA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0000209Protein polyubiquitinationTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0000502Proteasome complexTAScellular_component
GO:0002039P53 bindingIDAmolecular_function
GO:0002474Antigen processing and presentation of peptide antigen via MHC class ITASbiological_process
GO:0002479Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTASbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0006521Regulation of cellular amino acid metabolic processTASbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestTASbiological_process
GO:0008537Proteasome activator complexIEAcellular_component
GO:0010467Gene expressionTASbiological_process
GO:0010950Positive regulation of endopeptidase activityIDAbiological_process
GO:0010952Positive regulation of peptidase activityIDAbiological_process
GO:0016032Viral processTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0031145Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processTASbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0042981Regulation of apoptotic processTASbiological_process
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0051436Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051437Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051439Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0052547Regulation of peptidase activityIDAbiological_process
GO:0052548Regulation of endopeptidase activityIDAbiological_process
GO:0061133Endopeptidase activator activityIDAmolecular_function
GO:0061136Regulation of proteasomal protein catabolic processIDAbiological_process
GO:0097371MDM2/MDM4 family protein bindingIDAmolecular_function
GO:2001237Negative regulation of extrinsic apoptotic signaling pathwayIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.04700784540.68951850610.48026444361.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.4605609447
GSE13712_SHEARUp0.2238811471
GSE13712_STATICUp0.2976652118
GSE19018Down-0.7692573775
GSE19899_A1Up0.0961363340
GSE19899_A2Up0.8391396927
PubMed_21979375_A1Up1.0118153770
PubMed_21979375_A2Up0.9310928358
GSE35957Down-0.0118934498
GSE36640Down-0.1020082036
GSE54402Up0.6194482466
GSE9593Down-0.1693898930
GSE43922Up0.2229354907
GSE24585Down-0.4255516902
GSE37065Down-0.0653281871
GSE28863_A1Down-0.0449812654
GSE28863_A2Up0.1517394182
GSE28863_A3Down-0.2336098073
GSE28863_A4Up0.1700455669
GSE48662Down-0.1554419370

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-7-5pMIMAT0000252MIRT004063Microarray//Microarray;OtherFunctional MTI (Weak)19073608
hsa-miR-155-5pMIMAT0000646MIRT020956ProteomicsFunctional MTI (Weak)18668040
hsa-miR-124-3pMIMAT0000422MIRT022991Proteomics;MicroarrayFunctional MTI (Weak)18668037
hsa-miR-24-3pMIMAT0000080MIRT030577MicroarrayFunctional MTI (Weak)19748357
hsa-miR-16-5pMIMAT0000069MIRT031898ProteomicsFunctional MTI (Weak)18668040
hsa-miR-16-5pMIMAT0000069MIRT031898CLASHFunctional MTI (Weak)23622248
hsa-let-7b-5pMIMAT0000063MIRT032477ProteomicsFunctional MTI (Weak)18668040
hsa-let-7b-5pMIMAT0000063MIRT032477CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT042151CLASHFunctional MTI (Weak)23622248
hsa-miR-324-5pMIMAT0000761MIRT043211CLASHFunctional MTI (Weak)23622248
hsa-miR-331-3pMIMAT0000760MIRT043475CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23766372REGgamma deficiency promotes premature aging via the casein kinase 1 pathway
23766372Antibody array analysis led us to identify CK1delta as a direct target of REGgamma
23766372Interestingly, a massive increase of p53 in REGgamma(-/-) tissues is associated with reduced Mdm2 protein levels despite that Mdm2 transcription is enhanced
23766372Furthermore, introducing exogenous Mdm2 to REGgamma(-/-) MEFs significantly rescues the phenotype of cellular senescence, thereby establishing a REGgamma-CK1-Mdm2-p53 regulatory pathway
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