HCSGD entry for ALYREF
1. General information
| Official gene symbol | ALYREF |
|---|---|
| Entrez ID | 10189 |
| Gene full name | Aly/REF export factor |
| Other gene symbols | ALY ALY/REF BEF REF THOC4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000018 | Regulation of DNA recombination | IMP | biological_process |
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0000346 | Transcription export complex | IDA | cellular_component |
| GO:0000398 | MRNA splicing, via spliceosome | IC TAS | biological_process |
| GO:0003697 | Single-stranded DNA binding | IEA | molecular_function |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006369 | Termination of RNA polymerase II transcription | TAS | biological_process |
| GO:0006406 | MRNA export from nucleus | IMP TAS | biological_process |
| GO:0008380 | RNA splicing | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016607 | Nuclear speck | IEA | cellular_component |
| GO:0031124 | MRNA 3'-end processing | TAS | biological_process |
| GO:0031297 | Replication fork processing | IMP | biological_process |
| GO:0032786 | Positive regulation of DNA-templated transcription, elongation | IMP | biological_process |
| GO:0035145 | Exon-exon junction complex | IDA | cellular_component |
| GO:0046784 | Viral mRNA export from host cell nucleus | IDA | biological_process |
| GO:0071013 | Catalytic step 2 spliceosome | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8488420995 | 0.0088697998 | 0.9999902473 | 0.1869191353 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2880818415 |
| GSE13712_SHEAR | Up | 0.7903389029 |
| GSE13712_STATIC | Up | 0.5887262701 |
| GSE19018 | Down | -0.2112550059 |
| GSE19899_A1 | Down | -0.8344125705 |
| GSE19899_A2 | Down | -0.3357068815 |
| PubMed_21979375_A1 | Down | -0.4440647964 |
| PubMed_21979375_A2 | Down | -1.4063925857 |
| GSE35957 | Down | -1.1608046771 |
| GSE36640 | Down | -2.2476707422 |
| GSE54402 | Up | 0.2813497758 |
| GSE9593 | Down | -0.9929603915 |
| GSE43922 | Down | -0.3150996530 |
| GSE24585 | Up | 0.0022125274 |
| GSE37065 | Down | -0.3030681440 |
| GSE28863_A1 | Down | -0.1512616869 |
| GSE28863_A2 | Down | -0.1063992940 |
| GSE28863_A3 | Up | 0.2764867583 |
| GSE28863_A4 | Up | 0.0082203268 |
| GSE48662 | Down | -0.0179771314 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-615-3p | MIMAT0003283 | MIRT040160 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-505-3p | MIMAT0002876 | MIRT041026 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045564 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
