HCSGD entry for G3BP1
1. General information
| Official gene symbol | G3BP1 |
|---|---|
| Entrez ID | 10146 |
| Gene full name | GTPase activating protein (SH3 domain) binding protein 1 |
| Other gene symbols | G3BP HDH-VIII |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003729 | MRNA binding | IEA | molecular_function |
| GO:0004003 | ATP-dependent DNA helicase activity | TAS | molecular_function |
| GO:0004004 | ATP-dependent RNA helicase activity | TAS | molecular_function |
| GO:0004519 | Endonuclease activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005622 | Intracellular | IEA | cellular_component |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0006200 | ATP catabolic process | TAS | biological_process |
| GO:0006810 | Transport | IEA | biological_process |
| GO:0007265 | Ras protein signal transduction | TAS | biological_process |
| GO:0008152 | Metabolic process | TAS | biological_process |
| GO:0010494 | Cytoplasmic stress granule | IEA | cellular_component |
| GO:0032508 | DNA duplex unwinding | TAS | biological_process |
| GO:0090090 | Negative regulation of canonical Wnt signaling pathway | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7111117663 | 0.4732245165 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0744581537 |
| GSE13712_SHEAR | Up | 0.1404087757 |
| GSE13712_STATIC | Up | 0.0838982418 |
| GSE19018 | Down | -0.2161211154 |
| GSE19899_A1 | Down | -0.0300474372 |
| GSE19899_A2 | Down | -0.1063386196 |
| PubMed_21979375_A1 | Down | -0.4023148403 |
| PubMed_21979375_A2 | Up | 0.1172387089 |
| GSE35957 | Up | 0.3193940053 |
| GSE36640 | Down | -0.3684749353 |
| GSE54402 | Up | 0.0625004704 |
| GSE9593 | Down | -0.0306806252 |
| GSE43922 | Up | 0.1441607981 |
| GSE24585 | Down | -0.1502717814 |
| GSE37065 | Down | -0.0159314872 |
| GSE28863_A1 | Up | 0.3018782950 |
| GSE28863_A2 | Up | 0.2593375828 |
| GSE28863_A3 | Down | -0.3045402264 |
| GSE28863_A4 | Down | -0.0158192974 |
| GSE48662 | Down | -0.2069986483 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT002572 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002572 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT005163 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-23b-3p | MIMAT0000418 | MIRT023470 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-1 | MIMAT0000416 | MIRT024102 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-320b | MIMAT0005792 | MIRT036199 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-941 | MIMAT0004984 | MIRT036580 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037518 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040861 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041227 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042020 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044514 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045198 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30b-5p | MIMAT0000420 | MIRT046135 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-197-3p | MIMAT0000227 | MIRT048116 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1260b | MIMAT0015041 | MIRT052672 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
