HCSGD entry for OPTN
1. General information
| Official gene symbol | OPTN |
|---|---|
| Entrez ID | 10133 |
| Gene full name | optineurin |
| Other gene symbols | ALS12 FIP2 GLC1E HIP7 HYPL NRP TFIIIA-INTP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000042 | Protein targeting to Golgi | IMP | biological_process |
| GO:0000086 | G2/M transition of mitotic cell cycle | TAS | biological_process |
| GO:0000139 | Golgi membrane | TAS | cellular_component |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005802 | Trans-Golgi network | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0007030 | Golgi organization | IMP | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0008022 | Protein C-terminus binding | IPI | molecular_function |
| GO:0008219 | Cell death | IEA | biological_process |
| GO:0043001 | Golgi to plasma membrane protein transport | IMP | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0090161 | Golgi ribbon formation | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0066207895 | 0.9517482428 | 0.2141507371 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0747394032 |
| GSE13712_SHEAR | Up | 0.3274120732 |
| GSE13712_STATIC | Up | 0.2396797445 |
| GSE19018 | Up | 0.7860601179 |
| GSE19899_A1 | Down | -0.0716387861 |
| GSE19899_A2 | Up | 0.7178931347 |
| PubMed_21979375_A1 | Down | -0.0186411233 |
| PubMed_21979375_A2 | Up | 0.2793886306 |
| GSE35957 | Up | 0.6287676689 |
| GSE36640 | Up | 1.0176377826 |
| GSE54402 | Down | -0.7521123791 |
| GSE9593 | Up | 1.4883985840 |
| GSE43922 | Up | 0.0038744858 |
| GSE24585 | Up | 0.6992171955 |
| GSE37065 | Up | 0.4773313616 |
| GSE28863_A1 | Up | 0.0454847189 |
| GSE28863_A2 | Up | 0.4507056840 |
| GSE28863_A3 | Down | -0.3029987011 |
| GSE28863_A4 | Up | 0.2753590926 |
| GSE48662 | Up | 0.1291778128 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT019128 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-9-5p | MIMAT0000441 | MIRT021455 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049818 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-3p | MIMAT0000071 | MIRT050771 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050845 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
