HCSGD entry for HIPK3
1. General information
| Official gene symbol | HIPK3 |
|---|---|
| Entrez ID | 10114 |
| Gene full name | homeodomain interacting protein kinase 3 |
| Other gene symbols | DYRK6 FIST3 PKY YAK1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004672 | Protein kinase activity | IDA | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IDA IEA ISS | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA IEA | cellular_component |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0009299 | MRNA transcription | IDA | biological_process |
| GO:0016605 | PML body | IEA | cellular_component |
| GO:0018105 | Peptidyl-serine phosphorylation | IEA ISS | biological_process |
| GO:0018107 | Peptidyl-threonine phosphorylation | IEA ISS | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | IMP | biological_process |
| GO:0043508 | Negative regulation of JUN kinase activity | IEA ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0057268303 | 0.9915810759 | 0.1985117647 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0352333409 |
| GSE13712_SHEAR | Up | 0.0599007836 |
| GSE13712_STATIC | Down | -0.1179920323 |
| GSE19018 | Down | -0.1140436027 |
| GSE19899_A1 | Up | 0.2489848322 |
| GSE19899_A2 | Up | 0.6404728003 |
| PubMed_21979375_A1 | Up | 1.2286755301 |
| PubMed_21979375_A2 | Up | 0.9936313144 |
| GSE35957 | Up | 0.6269571354 |
| GSE36640 | Up | 1.2213070891 |
| GSE54402 | Up | 0.1836129114 |
| GSE9593 | Up | 0.2384903627 |
| GSE43922 | Up | 0.4486794862 |
| GSE24585 | Up | 0.5114502729 |
| GSE37065 | Up | 0.1744789325 |
| GSE28863_A1 | Up | 0.4938147814 |
| GSE28863_A2 | Up | 0.5702359185 |
| GSE28863_A3 | Down | -0.3200278987 |
| GSE28863_A4 | Down | -0.0824483452 |
| GSE48662 | Up | 0.5317562087 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-20b-5p | MIMAT0001413 | MIRT001782 | Luciferase reporter assay | Functional MTI | 17575136 |
| hsa-miR-106a-5p | MIMAT0000103 | MIRT001837 | Luciferase reporter assay | Functional MTI | 17575136 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT004064 | Luciferase reporter assay | Functional MTI | 17575136 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT004090 | Luciferase reporter assay | Functional MTI | 17575136 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018461 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022918 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-1 | MIMAT0000416 | MIRT023984 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | NA | hsa-miR-21 | 17991735 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
