HCSGD entry for HUWE1
1. General information
| Official gene symbol | HUWE1 |
|---|---|
| Entrez ID | 10075 |
| Gene full name | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase |
| Other gene symbols | ARF-BP1 HECTH9 HSPC272 Ib772 LASU1 MULE URE-B1 UREB1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000209 | Protein polyubiquitination | IDA | biological_process |
| GO:0003677 | DNA binding | ISS | molecular_function |
| GO:0004842 | Ubiquitin-protein ligase activity | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA ISS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006284 | Base-excision repair | IMP | biological_process |
| GO:0006513 | Protein monoubiquitination | IDA | biological_process |
| GO:0016574 | Histone ubiquitination | IDA | biological_process |
| GO:0030154 | Cell differentiation | IEA | biological_process |
| GO:0042787 | Protein ubiquitination involved in ubiquitin-dependent protein catabolic process | IBA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0303710953 | 0.9365089738 | 0.4035828961 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0653448679 |
| GSE13712_SHEAR | Up | 0.0702897022 |
| GSE13712_STATIC | Up | 0.0288588377 |
| GSE19018 | Up | 0.0990399537 |
| GSE19899_A1 | Up | 0.1203196010 |
| GSE19899_A2 | Down | -0.1277592825 |
| PubMed_21979375_A1 | Up | 0.0853513198 |
| PubMed_21979375_A2 | Up | 0.0376486837 |
| GSE35957 | Up | 0.1476000860 |
| GSE36640 | Up | 0.0296016188 |
| GSE54402 | Up | 0.2820882357 |
| GSE9593 | Up | 0.0295796046 |
| GSE43922 | Down | -0.0512701298 |
| GSE24585 | Down | -0.0539653669 |
| GSE37065 | Down | -0.1379517584 |
| GSE28863_A1 | Up | 1.9253747276 |
| GSE28863_A2 | Up | 1.8745548893 |
| GSE28863_A3 | Up | 0.2025600061 |
| GSE28863_A4 | Up | 0.0358455125 |
| GSE48662 | Up | 0.2485854225 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025352 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-1303 | MIMAT0005891 | MIRT035882 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT036979 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-877-5p | MIMAT0004949 | MIRT037319 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-424-3p | MIMAT0004749 | MIRT038010 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-7-1-3p | MIMAT0004553 | MIRT038682 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30c-2-3p | MIMAT0004550 | MIRT038686 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-3p | MIMAT0004509 | MIRT038776 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-660-5p | MIMAT0003338 | MIRT039457 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041449 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042210 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042879 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-361-5p | MIMAT0000703 | MIRT044071 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-29c-3p | MIMAT0000681 | MIRT044240 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT044343 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044520 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045042 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045495 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT045992 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-181b-5p | MIMAT0000257 | MIRT047250 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT047319 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT048243 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT048861 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-29a-3p | MIMAT0000086 | MIRT049984 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050828 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7c-5p | MIMAT0000064 | MIRT051832 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT051966 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052488 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21522127 | USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1 |
| 21522127 | USP4 interacts directly with and deubiquitinates ARF-BP1, leading to the stabilization of ARF-BP1 and subsequent reduction of p53 levels |
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