HCSGD entry for NR1H3
1. General information
| Official gene symbol | NR1H3 |
|---|---|
| Entrez ID | 10062 |
| Gene full name | nuclear receptor subfamily 1, group H, member 3 |
| Other gene symbols | LXR-a LXRA RLD-1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA ISS | biological_process |
| GO:0000790 | Nuclear chromatin | IDA | cellular_component |
| GO:0003677 | DNA binding | TAS | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0003707 | Steroid hormone receptor activity | IEA | molecular_function |
| GO:0003713 | Transcription coactivator activity | TAS | molecular_function |
| GO:0004879 | Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA TAS | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0010745 | Negative regulation of macrophage derived foam cell differentiation | IC | biological_process |
| GO:0010867 | Positive regulation of triglyceride biosynthetic process | IMP | biological_process |
| GO:0010870 | Positive regulation of receptor biosynthetic process | IDA | biological_process |
| GO:0010875 | Positive regulation of cholesterol efflux | IDA IEA IMP | biological_process |
| GO:0010887 | Negative regulation of cholesterol storage | IEA IMP | biological_process |
| GO:0015485 | Cholesterol binding | TAS | molecular_function |
| GO:0032270 | Positive regulation of cellular protein metabolic process | IMP | biological_process |
| GO:0032369 | Negative regulation of lipid transport | IMP | biological_process |
| GO:0032376 | Positive regulation of cholesterol transport | IDA | biological_process |
| GO:0032570 | Response to progesterone | IDA | biological_process |
| GO:0032810 | Sterol response element binding | IDA | molecular_function |
| GO:0034145 | Positive regulation of toll-like receptor 4 signaling pathway | IDA | biological_process |
| GO:0042632 | Cholesterol homeostasis | IEA ISS | biological_process |
| GO:0042752 | Regulation of circadian rhythm | TAS | biological_process |
| GO:0043031 | Negative regulation of macrophage activation | IEA ISS | biological_process |
| GO:0043277 | Apoptotic cell clearance | IMP | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0044212 | Transcription regulatory region DNA binding | IDA IEA | molecular_function |
| GO:0044255 | Cellular lipid metabolic process | IEA | biological_process |
| GO:0045723 | Positive regulation of fatty acid biosynthetic process | IMP | biological_process |
| GO:0045861 | Negative regulation of proteolysis | IEA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IMP | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA IEA IMP | biological_process |
| GO:0048550 | Negative regulation of pinocytosis | IMP | biological_process |
| GO:0050728 | Negative regulation of inflammatory response | IEA ISS | biological_process |
| GO:0051006 | Positive regulation of lipoprotein lipase activity | IMP | biological_process |
| GO:0055088 | Lipid homeostasis | ISS | biological_process |
| GO:0055092 | Sterol homeostasis | ISS | biological_process |
| GO:0060336 | Negative regulation of interferon-gamma-mediated signaling pathway | NAS | biological_process |
| GO:0070328 | Triglyceride homeostasis | IEA ISS | biological_process |
| GO:0071222 | Cellular response to lipopolysaccharide | IDA IEA | biological_process |
| GO:0090188 | Negative regulation of pancreatic juice secretion | IEA ISS | biological_process |
| GO:0090341 | Negative regulation of secretion of lysosomal enzymes | IEA ISS | biological_process |
| GO:2000189 | Positive regulation of cholesterol homeostasis | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9954098970 | 0.0058873105 | 0.9999902473 | 0.1551324351 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0956792881 |
| GSE13712_SHEAR | Down | -1.0049640200 |
| GSE13712_STATIC | Down | -0.8743584314 |
| GSE19018 | Down | -0.3082145982 |
| GSE19899_A1 | Down | -0.4522743412 |
| GSE19899_A2 | Down | -1.6853119057 |
| PubMed_21979375_A1 | Down | -0.6841354421 |
| PubMed_21979375_A2 | Down | -0.4570119518 |
| GSE35957 | Down | -0.5754336910 |
| GSE36640 | Down | -0.4205048213 |
| GSE54402 | Down | -0.5252027911 |
| GSE9593 | Down | -0.8087185966 |
| GSE43922 | Down | -0.1187342373 |
| GSE24585 | Down | -0.2774518940 |
| GSE37065 | Down | -0.0378533955 |
| GSE28863_A1 | Down | -0.0797205009 |
| GSE28863_A2 | Down | -0.0378799157 |
| GSE28863_A3 | Up | 0.0375598346 |
| GSE28863_A4 | Up | 0.0948564817 |
| GSE48662 | Up | 0.3118705765 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE | DB07080 | - |
| N-(TERT-BUTYL)-3,5-DIMETHYL-N'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDE | DB07929 | - |
| 1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE | DB08063 | - |
| (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID | DB08175 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-613 | MIMAT0003281 | MIRT006068 | Luciferase reporter assay | Functional MTI | 23496987 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
