HCSGD entry for SMC4
1. General information
| Official gene symbol | SMC4 |
|---|---|
| Entrez ID | 10051 |
| Gene full name | structural maintenance of chromosomes 4 |
| Other gene symbols | CAP-C CAPC SMC-4 SMC4L1 hCAP-C |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000070 | Mitotic sister chromatid segregation | TAS | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0000796 | Condensin complex | IDA TAS | cellular_component |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA TAS | molecular_function |
| GO:0005634 | Nucleus | IDA TAS | cellular_component |
| GO:0005694 | Chromosome | IEA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006281 | DNA repair | IEA | biological_process |
| GO:0006310 | DNA recombination | IEA | biological_process |
| GO:0007076 | Mitotic chromosome condensation | IDA | biological_process |
| GO:0010032 | Meiotic chromosome condensation | IEA | biological_process |
| GO:0045132 | Meiotic chromosome segregation | IEA | biological_process |
| GO:0046982 | Protein heterodimerization activity | IPI | molecular_function |
| GO:0051276 | Chromosome organization | IEA | biological_process |
| GO:0051383 | Kinetochore organization | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9884244975 | 0.0000732913 | 0.9999902473 | 0.0145684211 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.8648663922 |
| GSE13712_SHEAR | Up | 0.0131673901 |
| GSE13712_STATIC | Down | -0.3926062298 |
| GSE19018 | Down | -0.2152085346 |
| GSE19899_A1 | Down | -1.8123712008 |
| GSE19899_A2 | Down | -3.1099925577 |
| PubMed_21979375_A1 | Down | -2.4928334596 |
| PubMed_21979375_A2 | Down | -3.5835810132 |
| GSE35957 | Down | -2.4505793190 |
| GSE36640 | Down | -3.3304884317 |
| GSE54402 | Down | -0.3799072325 |
| GSE9593 | Down | -1.1109120202 |
| GSE43922 | Down | -1.9641816473 |
| GSE24585 | Down | -0.0026890707 |
| GSE37065 | Down | -0.3196680790 |
| GSE28863_A1 | Up | 0.1101218998 |
| GSE28863_A2 | Up | 1.0434474065 |
| GSE28863_A3 | Down | -0.2402705951 |
| GSE28863_A4 | Down | -0.2193574855 |
| GSE48662 | Down | -1.3167365943 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT023841 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024583 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026547 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029636 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-484 | MIMAT0002174 | MIRT042211 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
