HCSGD entry for CDH3
1. General information
| Official gene symbol | CDH3 |
|---|---|
| Entrez ID | 1001 |
| Gene full name | cadherin 3, type 1, P-cadherin (placental) |
| Other gene symbols | CDHP HJMD PCAD |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IDA IEA TAS | cellular_component |
| GO:0005913 | Cell-cell adherens junction | IEA | cellular_component |
| GO:0007155 | Cell adhesion | TAS | biological_process |
| GO:0007156 | Homophilic cell adhesion | IEA | biological_process |
| GO:0007601 | Visual perception | IEA | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0034329 | Cell junction assembly | TAS | biological_process |
| GO:0034332 | Adherens junction organization | TAS | biological_process |
| GO:0042060 | Wound healing | IEA | biological_process |
| GO:0042493 | Response to drug | IEA | biological_process |
| GO:0045216 | Cell-cell junction organization | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2934476008 | 0.7868522966 | 0.9939305495 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1790322216 |
| GSE13712_SHEAR | Up | 0.2536905140 |
| GSE13712_STATIC | Down | -0.0868908478 |
| GSE19018 | Up | 0.0512387879 |
| GSE19899_A1 | Up | 0.1694378949 |
| GSE19899_A2 | Down | -0.0158246114 |
| PubMed_21979375_A1 | Up | 0.0118817045 |
| PubMed_21979375_A2 | Down | -0.1236971789 |
| GSE35957 | Up | 0.1774849229 |
| GSE36640 | Up | 0.0309387144 |
| GSE54402 | Up | 0.1144710199 |
| GSE9593 | Down | -0.2288457319 |
| GSE43922 | Up | 0.0165100031 |
| GSE24585 | Up | 1.0266831233 |
| GSE37065 | Down | -0.0966511715 |
| GSE28863_A1 | Up | 0.0205766497 |
| GSE28863_A2 | Up | 0.1394186354 |
| GSE28863_A3 | Down | -0.0072256485 |
| GSE28863_A4 | Up | 0.1306391387 |
| GSE48662 | Up | 0.1058002743 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017451 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-9-5p | MIMAT0000441 | MIRT021364 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-132-3p | MIMAT0000426 | MIRT021719 | Microarray | Functional MTI (Weak) | 17612493 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24245738 | In this study, we explore the role of vascular senescence in premature CAD (PCAD) in a developing country by comparing the numerical status and senescence of circulating EPCs in PCAD patients to controls |
| 24245738 | EPC-TA was reduced in PCAD patients, but was statistically significant only after adjustment for confounding factors (1 |
| 24245738 | CONCLUSIONS: We observed an association between increased vascular cell senescence with PCAD in a sample of young patients from India |
| 24245738 | This suggests that early accelerated vascular cell senescence may play an important mechanistic role in CAD epidemic in developing countries like India where PCAD burden is markedly higher compared to developed countries |
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