HCSGD entry for CDC42
1. General information
| Official gene symbol | CDC42 |
|---|---|
| Entrez ID | 998 |
| Gene full name | cell division cycle 42 |
| Other gene symbols | CDC42Hs G25K |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA ISS | cellular_component |
| GO:0002040 | Sprouting angiogenesis | IEA | biological_process |
| GO:0003161 | Cardiac conduction system development | IEA | biological_process |
| GO:0003334 | Keratinocyte development | IEA | biological_process |
| GO:0003924 | GTPase activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0005622 | Intracellular | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005815 | Microtubule organizing center | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA IEA TAS | cellular_component |
| GO:0006184 | GTP catabolic process | TAS | biological_process |
| GO:0007030 | Golgi organization | IEA ISS | biological_process |
| GO:0007088 | Regulation of mitosis | IEA | biological_process |
| GO:0007097 | Nuclear migration | IEA | biological_process |
| GO:0007163 | Establishment or maintenance of cell polarity | TAS | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007264 | Small GTPase mediated signal transduction | IEA TAS | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008152 | Metabolic process | TAS | biological_process |
| GO:0010628 | Positive regulation of gene expression | IEA | biological_process |
| GO:0010629 | Negative regulation of gene expression | IEA | biological_process |
| GO:0016020 | Membrane | IDA IEA | cellular_component |
| GO:0019901 | Protein kinase binding | IDA IPI | molecular_function |
| GO:0030036 | Actin cytoskeleton organization | IDA | biological_process |
| GO:0030141 | Secretory granule | IEA | cellular_component |
| GO:0030175 | Filopodium | IDA | cellular_component |
| GO:0030225 | Macrophage differentiation | TAS | biological_process |
| GO:0030496 | Midbody | IDA | cellular_component |
| GO:0030742 | GTP-dependent protein binding | IEA | molecular_function |
| GO:0031069 | Hair follicle morphogenesis | IEA | biological_process |
| GO:0031274 | Positive regulation of pseudopodium assembly | IDA | biological_process |
| GO:0031295 | T cell costimulation | TAS | biological_process |
| GO:0031333 | Negative regulation of protein complex assembly | IPI | biological_process |
| GO:0031424 | Keratinization | IEA | biological_process |
| GO:0031435 | Mitogen-activated protein kinase kinase kinase binding | IEA | molecular_function |
| GO:0031647 | Regulation of protein stability | IEA | biological_process |
| GO:0031996 | Thioesterase binding | IPI | molecular_function |
| GO:0032467 | Positive regulation of cytokinesis | IMP | biological_process |
| GO:0033138 | Positive regulation of peptidyl-serine phosphorylation | IEA | biological_process |
| GO:0034191 | Apolipoprotein A-I receptor binding | IPI | molecular_function |
| GO:0034332 | Adherens junction organization | IEA | biological_process |
| GO:0034613 | Cellular protein localization | IEA | biological_process |
| GO:0035088 | Establishment or maintenance of apical/basal cell polarity | IEA | biological_process |
| GO:0035264 | Multicellular organism growth | IEA | biological_process |
| GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | TAS | biological_process |
| GO:0042059 | Negative regulation of epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0042176 | Regulation of protein catabolic process | IEA | biological_process |
| GO:0042692 | Muscle cell differentiation | TAS | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0042995 | Cell projection | IEA | cellular_component |
| GO:0043005 | Neuron projection | IDA | cellular_component |
| GO:0043025 | Neuronal cell body | IDA | cellular_component |
| GO:0043497 | Regulation of protein heterodimerization activity | IEA | biological_process |
| GO:0043525 | Positive regulation of neuron apoptotic process | IEA | biological_process |
| GO:0043552 | Positive regulation of phosphatidylinositol 3-kinase activity | IEA | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0045177 | Apical part of cell | IEA | cellular_component |
| GO:0045740 | Positive regulation of DNA replication | IEA | biological_process |
| GO:0045859 | Regulation of protein kinase activity | IEA | biological_process |
| GO:0046330 | Positive regulation of JNK cascade | IEA | biological_process |
| GO:0046847 | Filopodium assembly | IEA | biological_process |
| GO:0048554 | Positive regulation of metalloenzyme activity | IEA | biological_process |
| GO:0048664 | Neuron fate determination | IEA | biological_process |
| GO:0051017 | Actin filament bundle assembly | IEA | biological_process |
| GO:0051056 | Regulation of small GTPase mediated signal transduction | TAS | biological_process |
| GO:0051149 | Positive regulation of muscle cell differentiation | TAS | biological_process |
| GO:0051233 | Spindle midzone | IDA | cellular_component |
| GO:0051489 | Regulation of filopodium assembly | IDA | biological_process |
| GO:0051683 | Establishment of Golgi localization | IEA ISS | biological_process |
| GO:0051835 | Positive regulation of synapse structural plasticity | IEA | biological_process |
| GO:0051988 | Regulation of attachment of spindle microtubules to kinetochore | IMP | biological_process |
| GO:0060047 | Heart contraction | IEA | biological_process |
| GO:0060070 | Canonical Wnt signaling pathway | IEA | biological_process |
| GO:0060661 | Submandibular salivary gland formation | IEA | biological_process |
| GO:0060684 | Epithelial-mesenchymal cell signaling | IEA | biological_process |
| GO:0060789 | Hair follicle placode formation | IEA | biological_process |
| GO:0071338 | Positive regulation of hair follicle cell proliferation | IEA | biological_process |
| GO:0072384 | Organelle transport along microtubule | IEA ISS | biological_process |
| GO:0072686 | Mitotic spindle | IDA | cellular_component |
| GO:0090135 | Actin filament branching | IEA | biological_process |
| GO:0090136 | Epithelial cell-cell adhesion | IEA | biological_process |
| GO:0090316 | Positive regulation of intracellular protein transport | IEA | biological_process |
| GO:1900026 | Positive regulation of substrate adhesion-dependent cell spreading | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5807940504 | 0.7489177919 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0486574563 |
| GSE13712_SHEAR | Up | 0.0502517892 |
| GSE13712_STATIC | Up | 0.1134837994 |
| GSE19018 | Down | -0.0311537877 |
| GSE19899_A1 | Down | -0.0573518788 |
| GSE19899_A2 | Up | 0.0712517368 |
| PubMed_21979375_A1 | Up | 0.0614636798 |
| PubMed_21979375_A2 | Down | -0.0118223579 |
| GSE35957 | Down | -0.2328967645 |
| GSE36640 | Down | -0.0055262550 |
| GSE54402 | Up | 0.2514977639 |
| GSE9593 | Down | -0.1289614427 |
| GSE43922 | Up | 0.0479279822 |
| GSE24585 | Up | 0.0420781707 |
| GSE37065 | Up | 0.0110309442 |
| GSE28863_A1 | Down | -0.0866656652 |
| GSE28863_A2 | Up | 0.0206119814 |
| GSE28863_A3 | Up | 0.3686670168 |
| GSE28863_A4 | Down | -0.0511191875 |
| GSE48662 | Down | -0.0259257871 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Aminophosphonic Acid-Guanylate Ester | DB02623 | EXPT01626 |
| Guanosine-5'-Diphosphate | DB04315 | EXPT01573 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-224-5p | MIMAT0000281 | MIRT000636 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20023705 |
| hsa-miR-29a-3p | MIMAT0000086 | MIRT006490 | Luciferase reporter assay//Western blot | Functional MTI | 19079265 |
| hsa-miR-29c-3p | MIMAT0000681 | MIRT006489 | Luciferase reporter assay//Western blot | Functional MTI | 19079265 |
| hsa-miR-185-5p | MIMAT0000455 | MIRT004037 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 21186079 |
| hsa-miR-29b-3p | MIMAT0000100 | MIRT006488 | Luciferase reporter assay//Western blot | Functional MTI | 19079265 |
| hsa-miR-137 | MIMAT0000429 | MIRT005485 | Luciferase reporter assay//Western blot//Reporter assay;Other | Functional MTI | 20473940 |
| hsa-miR-137 | MIMAT0000429 | MIRT005485 | Luciferase reporter assay | Functional MTI | 23178712 |
| hsa-miR-216a-5p | MIMAT0000273 | MIRT005964 | Immunohistochemistry//Luciferase reporter assay//Western blot | Functional MTI | 21149267 |
| hsa-miR-330-3p | MIMAT0000751 | MIRT005965 | Immunohistochemistry//Luciferase reporter assay//Western blot | Functional MTI | 21149267 |
| hsa-miR-330-3p | MIMAT0000751 | MIRT005965 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 23337504 |
| hsa-miR-608 | MIMAT0003276 | MIRT005966 | Immunohistochemistry//Luciferase reporter assay//Western blot | Functional MTI | 21149267 |
| hsa-miR-195-5p | MIMAT0000461 | MIRT006995 | Luciferase reporter assay | Functional MTI | 22802111 |
| hsa-miR-375 | MIMAT0000728 | MIRT019885 | qRT-PCR;Microarray | Functional MTI (Weak) | 20584986 |
| hsa-miR-1 | MIMAT0000416 | MIRT023726 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-93-3p | MIMAT0004509 | MIRT038837 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041813 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT044369 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-29a-3p | MIMAT0000086 | 3 | hsa-miR-29a | {Western blot} | {overexpression by mature miRNA transfection} | 19079265 | |
| hsa-miR-29a-3p | MIMAT0000086 | 2 | hsa-miR-29a | {Western blot} | {overexpression by mature miRNA transfection} | 19079265 | |
| hsa-miR-29c-3p | MIMAT0000681 | 1 | hsa-miR-29c | {Western blot} | {overexpression by miRNA precursor transfection} | 19079265 | |
| hsa-miR-29c-3p | MIMAT0000681 | 2 | hsa-miR-29c | {Western blot} | {overexpression by miRNA precursor transfection} | 19079265 | |
| hsa-miR-29b-3p | MIMAT0000100 | 2 | hsa-miR-29b | {Western blot} | {overexpression by mature miRNA transfection} | 19079265 | |
| hsa-miR-29b-3p | MIMAT0000100 | 1 | hsa-miR-29b | {Western blot} | {overexpression by mature miRNA transfection} | 19079265 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 8 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26658759 | The Rho family GTPases Rac1 and Cdc42 were activated in senescent cells, and simvastatin reduced both activities |
| 26658759 | Further, geranylgeranyl transferase, Rac1 or Cdc42 depletion reduced IL-6 secretion by senescent cells |
| 25220425 | Regulation of hematopoietic stem cell aging by the small RhoGTPase Cdc42 |
| 25220425 | In this review article, we introduce the canonical set of phenotypes associated with aged HSCs, focus on the novel aging-associated phenotype apolarity caused by elevated activity of the small RhoGTPase in aged HSCs, discuss the role of Cdc42 in hematopoiesis and describe that pharmacological inhibition of Cdc42 activity in aged HSCs results in functionally young and thus rejuvenated HSCs |
| 24141946 | Wnt5a treatment of young HSCs induces ageing-associated stem-cell apolarity, reduction of regenerative capacity and an ageing-like myeloid-lymphoid differentiation skewing via activation of the small Rho GTPase Cdc42 |
| 22560076 | Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation |
| 22560076 | Here we demonstrate that elevated activity of the small RhoGTPase Cdc42 in aged HSCs is causally linked to HSC aging and correlates with a loss of polarity in aged HSCs |
| 22560076 | Pharmacological inhibition of Cdc42 activity functionally rejuvenates aged HSCs, increases the percentage of polarized cells in an aged HSC population, and restores the level and spatial distribution of histone H4 lysine 16 acetylation to a status similar to that seen in young HSCs |
| 22560076 | Our data therefore suggest a mechanistic role for Cdc42 activity in HSC biology and epigenetic regulation, and identify Cdc42 activity as a pharmacological target for ameliorating stem cell aging |
| 17404508 | Stem cells, aging, niche, adhesion and Cdc42: a model for changes in cell-cell interactions and hematopoietic stem cell aging |
| 17404508 | We recently published data indicating that aged primitive hematopoietic cells are less adhesive to stroma cells when compared to young cells and that this altered interaction might be due to elevated activity of the small RhoGTPase Cdc42 in aged cells |
| 17227869 | Cdc42 is a member of the Rho GTPase family known to regulate cell actin cytoskeleton organization, polarity, and growth, but its function in mammalian organismal physiology remains unclear |
| 17227869 | We found that natural aging of WT mice is marked with increased Cdc42 activity in various tissues |
| 17227869 | Furthermore, Cdc42 activation is sufficient to promote a premature cellular senescence phenotype that depends on p53 |
| 17227869 | These results suggest a role of Cdc42 activity in regulating mammalian genomic stability and aging-related physiology |
| 15263006 | Moreover, the Rho GTPases Rac1 and Cdc42 were found to be highly activated in senescent cells |
| 15263006 | Activated Rac1 and Cdc42 directly interacted with caveolin-1 in senescent cells |
| 12426222 | Retarded intracellular lipid transport associated with reduced expression of Cdc42, a member of Rho-GTPases, in human aged skin fibroblasts: a possible function of Cdc42 in mediating intracellular lipid transport |
| 12426222 | Recently, we raised the hypothesis that Cdc42, which is a member of the Rho-GTPase family and is known to play an important role in actin dynamics, might be important in cellular lipid transport |
| 12426222 | METHODS AND RESULTS: In the present study, we found that the protein expression levels and GTP-binding activities of Cdc42 were decreased in aged human skin fibroblasts |
| 12426222 | To correlate the decreased expression of Cdc42 with the retarded FRAP, we complemented the amount of wild-type c-myc-tagged Cdc42Hs (myc-Cdc42Hs-WT) by adenovirus-mediated gene transfer |
| 12426222 | CONCLUSIONS: These data clearly indicate that the expression of Cdc42, a small G protein, is decreased in the aged cells in close association with the retarded intracellular lipid transport |
| 12426222 | The present study demonstrates a possible function of Cdc42 in the mediation of intracellular lipid transport |
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