HCSGD entry for NR1H4

1. General information

Official gene symbolNR1H4
Entrez ID9971
Gene full namenuclear receptor subfamily 1, group H, member 4
Other gene symbolsBAR FXR HRR-1 HRR1 RIP14
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA bindingIDAmolecular_function
GO:0001080Nitrogen catabolite activation of transcription from RNA polymerase II promoterICbiological_process
GO:0001190RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcriptionIDAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEA TASmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0003707Steroid hormone receptor activityIEAmolecular_function
GO:0003713Transcription coactivator activityTASmolecular_function
GO:0003714Transcription corepressor activityTASmolecular_function
GO:0004879Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityISSmolecular_function
GO:0004887Thyroid hormone receptor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005719Nuclear euchromatinIDAcellular_component
GO:0006109Regulation of carbohydrate metabolic processIEAbiological_process
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0008206Bile acid metabolic processIEAbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0009749Response to glucoseIEAbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016922Ligand-dependent nuclear receptor bindingTASmolecular_function
GO:0030522Intracellular receptor signaling pathwayISSbiological_process
GO:0032052Bile acid bindingISS TASmolecular_function
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0034255Regulation of urea metabolic processISSbiological_process
GO:0038181Bile acid receptor activityIDAmolecular_function
GO:0038185Intracellular bile acid receptor signaling pathwayIDAbiological_process
GO:0042277Peptide bindingIEAmolecular_function
GO:0043565Sequence-specific DNA bindingIDA IEAmolecular_function
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIMPbiological_process
GO:0046965Retinoid X receptor bindingIEAmolecular_function
GO:0048565Digestive tract developmentIEAbiological_process
GO:0070857Regulation of bile acid biosynthetic processTASbiological_process
GO:0070858Negative regulation of bile acid biosynthetic processIDAbiological_process
GO:0071229Cellular response to acidIDAbiological_process
GO:0071417Cellular response to organonitrogen compoundISSbiological_process
GO:0090181Regulation of cholesterol metabolic processTASbiological_process
GO:1902122Chenodeoxycholic acid bindingIDAmolecular_function
GO:2000213Positive regulation of glutamate metabolic processISSbiological_process
GO:2001250Positive regulation of ammonia assimilation cycleIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.77752381750.83306557880.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0052501880
GSE13712_SHEARDown-0.0552626390
GSE13712_STATICUp0.1190517129
GSE19018Down-0.0129473006
GSE19899_A1Up0.1274018238
GSE19899_A2Up0.0285462869
PubMed_21979375_A1Up0.0963203311
PubMed_21979375_A2Up0.0264674664
GSE35957Up0.0862158685
GSE36640Up0.0821493101
GSE54402Up0.0736506963
GSE9593Up0.0373005950
GSE43922Up0.0118004408
GSE24585Down-0.1967023778
GSE37065Down-0.1079497926
GSE28863_A1Down-0.1023963189
GSE28863_A2Up0.1116382355
GSE28863_A3Up0.1784315350
GSE28863_A4Down-0.0191316451
GSE48662Down-0.0186062666

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

FexaramineDB02545 EXPT01424
Obeticholic acidDB05990 -
(8alpha,10alpha,13alpha,17beta)-17-[(4-hydroxyphenyl)carbonyl]androsta-3,5-diene-3-carboxylic acidDB08220 -

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.