HCSGD entry for MED12
1. General information
| Official gene symbol | MED12 |
|---|---|
| Entrez ID | 9968 |
| Gene full name | mediator complex subunit 12 |
| Other gene symbols | ARC240 CAGH45 FGS1 HOPA MED12S OHDOX OKS OPA1 TNRC11 TRAP230 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding | IEA | molecular_function |
| GO:0001104 | RNA polymerase II transcription cofactor activity | IDA IEA | molecular_function |
| GO:0001190 | RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription | IEA | molecular_function |
| GO:0001843 | Neural tube closure | IEA | biological_process |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0003712 | Transcription cofactor activity | IDA | molecular_function |
| GO:0003713 | Transcription coactivator activity | IDA | molecular_function |
| GO:0004872 | Receptor activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | IDA TAS | biological_process |
| GO:0007507 | Heart development | IEA | biological_process |
| GO:0008013 | Beta-catenin binding | IEA | molecular_function |
| GO:0008022 | Protein C-terminus binding | IPI | molecular_function |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0014003 | Oligodendrocyte development | IEA | biological_process |
| GO:0014044 | Schwann cell development | IEA | biological_process |
| GO:0016592 | Mediator complex | IDA IEA | cellular_component |
| GO:0019827 | Stem cell maintenance | IEA | biological_process |
| GO:0019904 | Protein domain specific binding | IPI | molecular_function |
| GO:0030178 | Negative regulation of Wnt signaling pathway | IMP | biological_process |
| GO:0030374 | Ligand-dependent nuclear receptor transcription coactivator activity | NAS | molecular_function |
| GO:0030518 | Intracellular steroid hormone receptor signaling pathway | IDA | biological_process |
| GO:0030521 | Androgen receptor signaling pathway | IDA | biological_process |
| GO:0042809 | Vitamin D receptor binding | NAS | molecular_function |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0046966 | Thyroid hormone receptor binding | IDA | molecular_function |
| GO:0060070 | Canonical Wnt signaling pathway | IEA | biological_process |
| GO:0060071 | Wnt signaling pathway, planar cell polarity pathway | IEA | biological_process |
| GO:0090245 | Axis elongation involved in somitogenesis | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4372276851 | 0.0832393564 | 0.9999902473 | 0.5471885864 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0452137599 |
| GSE13712_SHEAR | Down | -0.4619168902 |
| GSE13712_STATIC | Down | -0.6024438203 |
| GSE19018 | Down | -0.0531539263 |
| GSE19899_A1 | Down | -0.1230243552 |
| GSE19899_A2 | Down | -0.7842920250 |
| PubMed_21979375_A1 | Down | -0.7082785058 |
| PubMed_21979375_A2 | Up | 0.1911389485 |
| GSE35957 | Down | -0.1935988893 |
| GSE36640 | Down | -0.0984673564 |
| GSE54402 | Down | -0.0806207203 |
| GSE9593 | Down | -0.2362503206 |
| GSE43922 | Down | -0.5785193792 |
| GSE24585 | Down | -0.0012983721 |
| GSE37065 | Down | -0.1313551735 |
| GSE28863_A1 | Up | 1.5220111677 |
| GSE28863_A2 | Up | 1.1329844368 |
| GSE28863_A3 | Up | 0.1027565383 |
| GSE28863_A4 | Down | -0.1299746687 |
| GSE48662 | Up | 0.0782603502 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-454-3p | MIMAT0003885 | MIRT039241 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044626 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047700 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT048228 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048529 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-99a-5p | MIMAT0000097 | MIRT048665 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-31-5p | MIMAT0000089 | MIRT049860 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050915 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051310 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
