HCSGD entry for P2RY14
1. General information
| Official gene symbol | P2RY14 |
|---|---|
| Entrez ID | 9934 |
| Gene full name | purinergic receptor P2Y, G-protein coupled, 14 |
| Other gene symbols | GPR105 P2Y14 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0007186 | G-protein coupled receptor signaling pathway | NAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA NAS | cellular_component |
| GO:0045028 | G-protein coupled purinergic nucleotide receptor activity | IEA | molecular_function |
| GO:0045029 | UDP-activated nucleotide receptor activity | NAS | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4634184302 | 0.8753212568 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3135824438 |
| GSE13712_SHEAR | Up | 0.1309262071 |
| GSE13712_STATIC | Down | -0.2904771624 |
| GSE19018 | Up | 0.0295580862 |
| GSE19899_A1 | Up | 0.0756113207 |
| GSE19899_A2 | Down | -0.1383383558 |
| PubMed_21979375_A1 | Up | 0.0960930225 |
| PubMed_21979375_A2 | Down | -0.1235313742 |
| GSE35957 | Up | 0.1220205128 |
| GSE36640 | Up | 0.2346736891 |
| GSE54402 | Up | 0.1941426723 |
| GSE9593 | Up | 0.0423242800 |
| GSE43922 | Up | 0.1015070053 |
| GSE24585 | Up | 0.0285634230 |
| GSE37065 | Up | 0.0825517151 |
| GSE28863_A1 | Down | -0.0414789577 |
| GSE28863_A2 | Up | 0.1523741719 |
| GSE28863_A3 | Down | -0.0165603255 |
| GSE28863_A4 | Up | 0.0009569199 |
| GSE48662 | Up | 0.0068780661 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24937426 | Purinergic P2Y(1)(4) receptor modulates stress-induced hematopoietic stem/progenitor cell senescence |
| 24937426 | In mice, P2Y14 deficiency had no demonstrable effect under homeostatic conditions; however, radiation stress, aging, sequential exposure to chemotherapy, and serial bone marrow transplantation increased senescence in animals lacking P2Y14 |
| 24937426 | Treatment of WT cells with pertussis toxin recapitulated the P2Y14 phenotype, suggesting that P2Y14 mediates antisenescence effects through Gi/o protein-dependent pathways |
| 24937426 | Primitive hematopoietic cells lacking P2Y14 were compromised in their ability to restore hematopoiesis in irradiated mice |
| 24937426 | Together, these data indicate that P2Y14 on stem/progenitor cells of the hematopoietic system inhibits cell senescence by monitoring and responding to the extracellular manifestations of tissue stress and suggest that P2Y14-mediated responses prevent the premature decline of regenerative capacity after injury |
| 17982416 | The P2Y receptor agonists listed above induced a concentration-dependent rise in intracellular calcium in the TM cells |
| 17982416 | Cells at passage 18 showed significantly lower levels of intracellular calcium induced by ATP (36%), UTP (34%), and ADP (52%) compared to cells at passage 2, independent from any changes in P2Y receptor changes in expression |
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