HCSGD entry for CDC25A
1. General information
| Official gene symbol | CDC25A |
|---|---|
| Entrez ID | 993 |
| Gene full name | cell division cycle 25A |
| Other gene symbols | CDC25A2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000079 | Regulation of cyclin-dependent protein serine/threonine kinase activity | TAS | biological_process |
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0000086 | G2/M transition of mitotic cell cycle | TAS | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0004725 | Protein tyrosine phosphatase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005622 | Intracellular | IEA | cellular_component |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006260 | DNA replication | TAS | biological_process |
| GO:0007067 | Mitosis | IEA | biological_process |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0009314 | Response to radiation | IDA | biological_process |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0034644 | Cellular response to UV | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9655610425 | 0.0067390031 | 0.9999902473 | 0.1645429499 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2371958244 |
| GSE13712_SHEAR | Up | 0.4364709989 |
| GSE13712_STATIC | Up | 0.3412879252 |
| GSE19018 | Down | -0.5864995406 |
| GSE19899_A1 | Down | -0.3148212019 |
| GSE19899_A2 | Down | -1.4199986165 |
| PubMed_21979375_A1 | Down | -0.4415653819 |
| PubMed_21979375_A2 | Down | -1.9697641194 |
| GSE35957 | Down | -0.8002236381 |
| GSE36640 | Down | -2.6907805515 |
| GSE54402 | Down | -0.0760448687 |
| GSE9593 | Down | -0.4527357496 |
| GSE43922 | Down | -0.0238804612 |
| GSE24585 | Up | 0.0870354311 |
| GSE37065 | Down | -0.2134385509 |
| GSE28863_A1 | Down | -0.1022342831 |
| GSE28863_A2 | Up | 0.3027797164 |
| GSE28863_A3 | Up | 0.0479477528 |
| GSE28863_A4 | Up | 0.0264778620 |
| GSE48662 | Down | -0.7829167869 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | MIRT000157 | Microarray//Northern blot//qRT-PCR | Functional MTI (Weak) | 19826040 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT000157 | Luciferase reporter assay | Functional MTI | 23496142 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT000157 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-15a-5p | MIMAT0000068 | MIRT000284 | Luciferase reporter assay | Functional MTI | 18949056 |
| hsa-miR-503-5p | MIMAT0002874 | MIRT000648 | Luciferase reporter assay | Functional MTI | 19956200 |
| hsa-miR-424-5p | MIMAT0001341 | MIRT000655 | Luciferase reporter assay | Functional MTI | 19956200 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT001011 | Western blot | Non-Functional MTI | 18406353 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT002296 | Immunohistochemistry//qRT-PCR | Functional MTI (Weak) | 19966857 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT002296 | Luciferase reporter assay//Microarray//Western blot | Functional MTI | 17699775 |
| hsa-miR-449a | MIMAT0001541 | MIRT003186 | Luciferase reporter assay//Microarray//qRT-PCR//Western blot//Reporter assay;Western blot;Other | Functional MTI | 19833767 |
| hsa-miR-449b-5p | MIMAT0003327 | MIRT016138 | Reporter assay;Western blot | Functional MTI | 19833767 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016313 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026127 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027018 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027421 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031451 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT036976 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040942 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041718 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7i-5p | MIMAT0000415 | MIRT046546 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049120 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-let-7b-5p | MIMAT0000063 | NA | hsa-let-7b | 18026111 | |||
| hsa-let-7b-5p | MIMAT0000063 | NA | hsa-let-7b | {Western blot} | {overexpression by miRNA precursor transfection} | 17699775 | |
| hsa-miR-125b-5p | MIMAT0000423 | NA | hsa-miR-125b | {Western blot} | {overexpression} | 19948152 | |
| hsa-miR-21-5p | MIMAT0000076 | 1 | hsa-miR-21 | {Western blot} | {knock out} | 19826040 | |
| hsa-miR-503-5p | MIMAT0002874 | 1 | hsa-miR-503 | {Western blot} | {overexpression by miRNA precursor transfection} | 21220732 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23496142 | These two cell-cycle regulators are indirectly regulated by miR-21 via its validated direct targets NFIB (Nuclear factor 1 B-type), a transcriptional inhibitor of p21(CIP) (1) , and CDC25A, which regulates CDK2 activity by dephosphorylation |
| 23496142 | Knock-down of either NFIB or CDC25A shows a phenocopy of over-expressing miR-21 in regard to cell-cycle arrest |
| 23276696 | This effect was accompanied by the increased expression of cyclin E and CDC25A and the significantly decreased expression of cyclin-dependent kinase inhibitors |
| 11103932 | Reduction of Cdc25A contributes to cyclin E1-Cdk2 inhibition at senescence in human mammary epithelial cells |
| 11103932 | The inhibition of cyclin E-cdk2 in senescent HMECs was accompanied by increased inhibitory phosphorylation of cdk2, in association with a progressive loss of Cdc25A |
| 11103932 | Recombinant Cdc25A strongly reactivated cyclin E-cdk2 from senescent HMECs suggesting that reduction of Cdc25A contributes to cyclin E-cdk2 inhibition and G1 arrest at senescence |
| 11103932 | Although ectopic expression of Cdc25A failed to extend the lifespan of HMECs, the exogenous Cdc25A appeared to lack activity in these cells, since it neither shortened the G1-to-S phase interval nor activated cyclin E-cdk2 |
| 11103932 | In contrast, in the breast cancer-derived MCF-7 line, Cdc25A overexpression increased both cyclin E-cdk2 activity and the S phase fraction |
| 11103932 | Thus, mechanisms leading to HMEC immortalization may involve not only the re-induction of Cdc25A expression, but also activation of this phosphatase |
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