HCSGD entry for PAN2

1. General information

Official gene symbolPAN2
Entrez ID9924
Gene full namePAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
Other gene symbolsUSP52
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:00001753'-5'-exoribonuclease activityIDAmolecular_function
GO:0000184Nuclear-transcribed mRNA catabolic process, nonsense-mediated decayIEAbiological_process
GO:0000288Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decayTASbiological_process
GO:0000289Nuclear-transcribed mRNA poly(A) tail shorteningTASbiological_process
GO:0000932Cytoplasmic mRNA processing bodyIEAcellular_component
GO:0003676Nucleic acid bindingIEAmolecular_function
GO:0004221Ubiquitin thiolesterase activityIEAmolecular_function
GO:0004535Poly(A)-specific ribonuclease activityIDA TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006511Ubiquitin-dependent protein catabolic processIEAbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0031251PAN complexIDAcellular_component
GO:0090305Nucleic acid phosphodiester bond hydrolysisIDA TASbiological_process
GO:0090501RNA phosphodiester bond hydrolysisIDA TASbiological_process
GO:0090503RNA phosphodiester bond hydrolysis, exonucleolyticIDA TASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.94450909920.02806500130.99999024730.3187775237

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1149180233
GSE13712_SHEARDown-0.6903185682
GSE13712_STATICDown-0.6120750322
GSE19018Down-0.1031411215
GSE19899_A1Down-0.2131349341
GSE19899_A2Down-0.8368072371
PubMed_21979375_A1Down-0.6608226122
PubMed_21979375_A2Down-0.1254513265
GSE35957Down-0.4280960199
GSE36640Down-0.2754719864
GSE54402Down-0.2935273220
GSE9593Down-0.5118088387
GSE43922Down-0.3629820134
GSE24585Up0.3094326485
GSE37065Down-0.0214980078
GSE28863_A1Up0.5102314013
GSE28863_A2Up0.2634864444
GSE28863_A3Down-0.4649459908
GSE28863_A4Up0.0236099699
GSE48662Down-0.2205954384

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-222-3pMIMAT0000279MIRT046587CLASHFunctional MTI (Weak)23622248
hsa-miR-29a-3pMIMAT0000086MIRT049988CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.