HCSGD entry for IQSEC1
1. General information
| Official gene symbol | IQSEC1 |
|---|---|
| Entrez ID | 9922 |
| Gene full name | IQ motif and Sec7 domain 1 |
| Other gene symbols | ARF-GEP100 ARFGEP100 BRAG2 GEP100 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005086 | ARF guanyl-nucleotide exchange factor activity | IBA IEA | molecular_function |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005802 | Trans-Golgi network | IBA | cellular_component |
| GO:0016192 | Vesicle-mediated transport | IBA | biological_process |
| GO:0030036 | Actin cytoskeleton organization | IBA | biological_process |
| GO:0030054 | Cell junction | IDA | cellular_component |
| GO:0032012 | Regulation of ARF protein signal transduction | IEA | biological_process |
| GO:0043087 | Regulation of GTPase activity | IBA | biological_process |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3939241214 | 0.1063051366 | 0.9999902473 | 0.6243194779 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1497718976 |
| GSE13712_SHEAR | Down | -0.7012115370 |
| GSE13712_STATIC | Down | -0.3610874958 |
| GSE19018 | Up | 0.3380250023 |
| GSE19899_A1 | Down | -0.3176669177 |
| GSE19899_A2 | Down | -0.4591279644 |
| PubMed_21979375_A1 | Down | -1.9229914294 |
| PubMed_21979375_A2 | Up | 0.0936016787 |
| GSE35957 | Up | 0.0649106186 |
| GSE36640 | Up | 1.2166296690 |
| GSE54402 | Down | -0.1701809584 |
| GSE9593 | Up | 0.5483342154 |
| GSE43922 | Down | -0.2381216172 |
| GSE24585 | Down | -0.1899126542 |
| GSE37065 | Down | -0.0176337208 |
| GSE28863_A1 | Up | 0.2374125035 |
| GSE28863_A2 | Up | 0.3443769967 |
| GSE28863_A3 | Up | 0.1647291013 |
| GSE28863_A4 | Down | -0.1111623270 |
| GSE48662 | Up | 0.2738719269 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-92a-1-5p | MIMAT0004507 | MIRT038915 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-589-3p | MIMAT0003256 | MIRT040506 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-378a-5p | MIMAT0000731 | MIRT044004 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
