HCSGD entry for CDC6
1. General information
| Official gene symbol | CDC6 |
|---|---|
| Entrez ID | 990 |
| Gene full name | cell division cycle 6 |
| Other gene symbols | CDC18L HsCDC18 HsCDC6 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000076 | DNA replication checkpoint | TAS | biological_process |
| GO:0000079 | Regulation of cyclin-dependent protein serine/threonine kinase activity | TAS | biological_process |
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0000083 | Regulation of transcription involved in G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0000166 | Nucleotide binding | TAS | molecular_function |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0000922 | Spindle pole | IDA | cellular_component |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IEA TAS | cellular_component |
| GO:0005819 | Spindle | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006260 | DNA replication | TAS | biological_process |
| GO:0007067 | Mitosis | IEA | biological_process |
| GO:0007089 | Traversing start control point of mitotic cell cycle | TAS | biological_process |
| GO:0008156 | Negative regulation of DNA replication | TAS | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | TAS | biological_process |
| GO:0017111 | Nucleoside-triphosphatase activity | IEA | molecular_function |
| GO:0019900 | Kinase binding | IPI | molecular_function |
| GO:0030071 | Regulation of mitotic metaphase/anaphase transition | IMP | biological_process |
| GO:0032467 | Positive regulation of cytokinesis | IMP | biological_process |
| GO:0051233 | Spindle midzone | IDA | cellular_component |
| GO:0051984 | Positive regulation of chromosome segregation | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8718265187 | 0.0001331826 | 0.9999902473 | 0.0202630058 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4166436278 |
| GSE13712_SHEAR | Up | 0.2177590829 |
| GSE13712_STATIC | Up | 0.0893558661 |
| GSE19018 | Down | -0.6326663569 |
| GSE19899_A1 | Down | -0.9877448842 |
| GSE19899_A2 | Down | -4.2678491641 |
| PubMed_21979375_A1 | Down | -1.6153281315 |
| PubMed_21979375_A2 | Down | -5.8951664757 |
| GSE35957 | Down | -3.0172233008 |
| GSE36640 | Down | -3.8161009158 |
| GSE54402 | Down | -0.1677451313 |
| GSE9593 | Down | -1.7272657229 |
| GSE43922 | Down | -1.3568631738 |
| GSE24585 | Up | 0.3300390248 |
| GSE37065 | Down | -0.8067626563 |
| GSE28863_A1 | Down | -0.2236429551 |
| GSE28863_A2 | Up | 0.8070319283 |
| GSE28863_A3 | Down | -0.2367237560 |
| GSE28863_A4 | Up | 0.1388675757 |
| GSE48662 | Up | 0.0616505602 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26a-5p | MIMAT0000082 | MIRT001022 | Western blot | Non-Functional MTI | 18713946 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016523 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-142-3p | MIMAT0000434 | MIRT021602 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-361-3p | MIMAT0004682 | MIRT038272 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040157 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-501-5p | MIMAT0002872 | MIRT041141 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25772242 | We show that MOZ is required to maintain normal levels of histone 3 lysine 9 (H3K9) and H3K27 acetylation at the transcriptional start sites of at least four genes, Cdc6, Ezh2, E2f2 and Melk, and normal mRNA levels of these genes |
| 25772242 | CDC6, EZH2 and E2F2 are known inhibitors of the INK4A-ARF pathway |
| 25772242 | Using chromatin immunoprecipitation, we show that MOZ occupies the Cdc6, Ezh2 and Melk loci, thereby providing a direct link between MOZ, H3K9 and H3K27 acetylation, and normal transcriptional levels at these loci |
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