HCSGD entry for TBC1D4
1. General information
| Official gene symbol | TBC1D4 |
|---|---|
| Entrez ID | 9882 |
| Gene full name | TBC1 domain family, member 4 |
| Other gene symbols | AS160 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005097 | Rab GTPase activator activity | IEA | molecular_function |
| GO:0016192 | Vesicle-mediated transport | IMP | biological_process |
| GO:0030659 | Cytoplasmic vesicle membrane | TAS | cellular_component |
| GO:0031339 | Negative regulation of vesicle fusion | IEA | biological_process |
| GO:0032869 | Cellular response to insulin stimulus | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9226992705 | 0.0083970366 | 0.9999902473 | 0.1837602990 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4268447578 |
| GSE13712_SHEAR | Up | 0.4198798652 |
| GSE13712_STATIC | Down | -0.5620558548 |
| GSE19018 | Up | 0.0102517874 |
| GSE19899_A1 | Down | -0.4226471160 |
| GSE19899_A2 | Down | -0.8522939760 |
| PubMed_21979375_A1 | Down | -0.2616123029 |
| PubMed_21979375_A2 | Down | -1.3944313766 |
| GSE35957 | Down | -0.2756121725 |
| GSE36640 | Down | -0.4726701501 |
| GSE54402 | Down | -0.6542819075 |
| GSE9593 | Up | 1.1230526301 |
| GSE43922 | Down | -0.1532884236 |
| GSE24585 | Down | -0.4341029346 |
| GSE37065 | Down | -0.1079035712 |
| GSE28863_A1 | Up | 0.4396001361 |
| GSE28863_A2 | Up | 0.1375007087 |
| GSE28863_A3 | Down | -0.3636625400 |
| GSE28863_A4 | Down | -0.1977891896 |
| GSE48662 | Down | -0.5370500770 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-98-5p | MIMAT0000096 | MIRT027631 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028587 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT031138 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25263463 | Signalling impairment distal to Akt in phosphorylation of AS160 and FoxO1 was evident in senescent HepG2 cells |
| 22418434 | Consistent with this, insulin signaling was enhanced in the soleus muscle of MNUAK1KO mice, as evidenced by increased phosphorylation of IRS1 Tyr-608, AKT Thr-308, and TBC1D4 Thr-649 |
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