HCSGD entry for TLK1
1. General information
| Official gene symbol | TLK1 |
|---|---|
| Entrez ID | 9874 |
| Gene full name | tousled-like kinase 1 |
| Other gene symbols | PKU-beta |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001672 | Regulation of chromatin assembly or disassembly | IDA | biological_process |
| GO:0004674 | Protein serine/threonine kinase activity | IDA TAS | molecular_function |
| GO:0005524 | ATP binding | IDA | molecular_function |
| GO:0005634 | Nucleus | IDA TAS | cellular_component |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0006886 | Intracellular protein transport | IDA | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IEA | biological_process |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0016301 | Kinase activity | IEA | molecular_function |
| GO:0016568 | Chromatin modification | IEA | biological_process |
| GO:0035556 | Intracellular signal transduction | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6907765472 | 0.2571465028 | 0.9999902473 | 0.9720455407 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0853013214 |
| GSE13712_SHEAR | Down | -0.0603481465 |
| GSE13712_STATIC | Down | -0.0330622319 |
| GSE19018 | Down | -0.0098730256 |
| GSE19899_A1 | Down | -0.2045221657 |
| GSE19899_A2 | Down | -0.4734205053 |
| PubMed_21979375_A1 | Down | -0.5607213859 |
| PubMed_21979375_A2 | Down | -0.2189451142 |
| GSE35957 | Up | 0.4992286934 |
| GSE36640 | Up | 0.0677930643 |
| GSE54402 | Down | -0.3621057977 |
| GSE9593 | Up | 0.2813350316 |
| GSE43922 | Down | -0.3808036730 |
| GSE24585 | Up | 0.2873938559 |
| GSE37065 | Up | 0.1941667019 |
| GSE28863_A1 | Down | -0.1331026525 |
| GSE28863_A2 | Up | 0.2940724371 |
| GSE28863_A3 | Down | -0.2084090369 |
| GSE28863_A4 | Down | -0.0670703462 |
| GSE48662 | Up | 0.2024329776 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027139 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031590 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031590 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-28-5p | MIMAT0000085 | MIRT050002 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
