HCSGD entry for CDK1
1. General information
| Official gene symbol | CDK1 |
|---|---|
| Entrez ID | 983 |
| Gene full name | cyclin-dependent kinase 1 |
| Other gene symbols | CDC2 CDC28A P34CDC2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0000083 | Regulation of transcription involved in G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0000086 | G2/M transition of mitotic cell cycle | TAS | biological_process |
| GO:0000165 | MAPK cascade | TAS | biological_process |
| GO:0000186 | Activation of MAPKK activity | TAS | biological_process |
| GO:0000187 | Activation of MAPK activity | TAS | biological_process |
| GO:0000226 | Microtubule cytoskeleton organization | TAS | biological_process |
| GO:0000278 | Mitotic cell cycle | IEA TAS | biological_process |
| GO:0002224 | Toll-like receptor signaling pathway | TAS | biological_process |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | TAS | biological_process |
| GO:0002756 | MyD88-independent toll-like receptor signaling pathway | TAS | biological_process |
| GO:0004672 | Protein kinase activity | NAS | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0004693 | Cyclin-dependent protein serine/threonine kinase activity | IDA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IDA IEA | cellular_component |
| GO:0005739 | Mitochondrion | TAS | cellular_component |
| GO:0005815 | Microtubule organizing center | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005876 | Spindle microtubule | IDA | cellular_component |
| GO:0006260 | DNA replication | TAS | biological_process |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0006461 | Protein complex assembly | IEA | biological_process |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0007067 | Mitosis | IEA | biological_process |
| GO:0007077 | Mitotic nuclear envelope disassembly | TAS | biological_process |
| GO:0007095 | Mitotic G2 DNA damage checkpoint | IEA | biological_process |
| GO:0007098 | Centrosome cycle | TAS | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007264 | Small GTPase mediated signal transduction | TAS | biological_process |
| GO:0007265 | Ras protein signal transduction | TAS | biological_process |
| GO:0007344 | Pronuclear fusion | TAS | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0007569 | Cell aging | IEA | biological_process |
| GO:0008286 | Insulin receptor signaling pathway | TAS | biological_process |
| GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity | IDA | molecular_function |
| GO:0008543 | Fibroblast growth factor receptor signaling pathway | TAS | biological_process |
| GO:0009636 | Response to toxic substance | IEA | biological_process |
| GO:0010628 | Positive regulation of gene expression | IEA | biological_process |
| GO:0014038 | Regulation of Schwann cell differentiation | TAS | biological_process |
| GO:0014070 | Response to organic cyclic compound | IEA | biological_process |
| GO:0014075 | Response to amine | IEA | biological_process |
| GO:0014823 | Response to activity | IEA | biological_process |
| GO:0016477 | Cell migration | TAS | biological_process |
| GO:0030261 | Chromosome condensation | IEA | biological_process |
| GO:0030332 | Cyclin binding | IEA | molecular_function |
| GO:0030496 | Midbody | IDA | cellular_component |
| GO:0030544 | Hsp70 protein binding | IEA | molecular_function |
| GO:0031100 | Organ regeneration | IEA | biological_process |
| GO:0031145 | Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | TAS | biological_process |
| GO:0033160 | Positive regulation of protein import into nucleus, translocation | IEA | biological_process |
| GO:0034134 | Toll-like receptor 2 signaling pathway | TAS | biological_process |
| GO:0034138 | Toll-like receptor 3 signaling pathway | TAS | biological_process |
| GO:0034142 | Toll-like receptor 4 signaling pathway | TAS | biological_process |
| GO:0034146 | Toll-like receptor 5 signaling pathway | TAS | biological_process |
| GO:0034162 | Toll-like receptor 9 signaling pathway | TAS | biological_process |
| GO:0034166 | Toll-like receptor 10 signaling pathway | TAS | biological_process |
| GO:0034501 | Protein localization to kinetochore | IDA | biological_process |
| GO:0035173 | Histone kinase activity | IEA | molecular_function |
| GO:0035666 | TRIF-dependent toll-like receptor signaling pathway | TAS | biological_process |
| GO:0038095 | Fc-epsilon receptor signaling pathway | TAS | biological_process |
| GO:0038123 | Toll-like receptor TLR1:TLR2 signaling pathway | TAS | biological_process |
| GO:0038124 | Toll-like receptor TLR6:TLR2 signaling pathway | TAS | biological_process |
| GO:0042493 | Response to drug | IEA | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | IDA | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0045471 | Response to ethanol | IEA | biological_process |
| GO:0045740 | Positive regulation of DNA replication | IEA | biological_process |
| GO:0045931 | Positive regulation of mitotic cell cycle | IEA | biological_process |
| GO:0045995 | Regulation of embryonic development | TAS | biological_process |
| GO:0046686 | Response to cadmium ion | IEA | biological_process |
| GO:0046688 | Response to copper ion | IEA | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0048678 | Response to axon injury | IEA | biological_process |
| GO:0051403 | Stress-activated MAPK cascade | TAS | biological_process |
| GO:0051437 | Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | TAS | biological_process |
| GO:0051439 | Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | TAS | biological_process |
| GO:0055015 | Ventricular cardiac muscle cell development | IEA | biological_process |
| GO:0060045 | Positive regulation of cardiac muscle cell proliferation | IEA | biological_process |
| GO:0070301 | Cellular response to hydrogen peroxide | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9506039588 | 0.0000059800 | 0.9999902473 | 0.0069833333 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -2.3907921236 |
| GSE13712_SHEAR | Down | -0.6415715688 |
| GSE13712_STATIC | Down | -0.5669241598 |
| GSE19018 | Up | 0.0102622581 |
| GSE19899_A1 | Down | -2.4164362695 |
| GSE19899_A2 | Down | -5.7926415583 |
| PubMed_21979375_A1 | Down | -3.3111551836 |
| PubMed_21979375_A2 | Down | -7.0393629418 |
| GSE35957 | Down | -4.2271978429 |
| GSE36640 | Down | -4.5132641183 |
| GSE54402 | Down | -1.3550210044 |
| GSE9593 | Down | -1.9274531856 |
| GSE43922 | Down | -4.0878122058 |
| GSE24585 | Down | -0.2227556216 |
| GSE37065 | Down | -1.0720197668 |
| GSE28863_A1 | Down | -0.3297655728 |
| GSE28863_A2 | Up | 1.2505544064 |
| GSE28863_A3 | Down | -0.2557130154 |
| GSE28863_A4 | Up | 0.5380090741 |
| GSE48662 | Down | -2.6058030840 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Indirubin-3'-Monoxime | DB02052 | EXPT01949 |
| Olomoucine | DB02116 | EXPT02433 |
| Hymenialdisine | DB02950 | EXPT01757 |
| SU9516 | DB03428 | EXPT02974 |
| Flavopiridol | DB03496 | EXPT00998 |
| Alsterpaullone | DB04014 | EXPT00590 |
| AT7519 | DB05037 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-31-5p | MIMAT0000089 | MIRT007328 | Luciferase reporter assay | Functional MTI | 23233736 |
| hsa-miR-663a | MIMAT0003326 | MIRT016140 | Western blot;Other | Functional MTI | 20514450 |
| hsa-miR-590-3p | MIMAT0004801 | MIRT016189 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016442 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030503 | Microarray//Reporter assay;Western blot;qRT-PCR;Microarray;Other | Functional MTI | 19748357 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049057 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 7 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26476078 | Growth suppression was mediated by G1 blockade involving increased p21 expression and suppressed cyclin B1, CDK1, and CDC25C |
| 24827852 | RESULTS: The irradiated livers displayed several markers of cell senescence, including expression of senescence-associated-beta-galactosidase (SA-beta-gal), increase in cell size, and up-regulation of cyclin-dependent kinase inhibitors (CDK-I) p16 and p21 |
| 23907611 | Reconstitution of the cyclin B1/Cdk1 complex, a major regulator of the G2/M transition, failed to restore mitotic entry in hFis1-depleted cells |
| 23907611 | In contrast, expression of Plk1, an upstream regulator of the cyclin B1/Cdk1 complex, or FoxM1 (forkhead box M1), a master transcriptional factor for the cell cycle regulators of G2/M phase, restored the cell cycle in these cells |
| 23719597 | In primary PSC, doxorubicin treatment was associated with increased expression of interleukin-6 (IL-6) and matrix metalloproteinase (MMP)-9, while expression of the activation marker alpha-smooth muscle actin (alpha-SMA), p53, Cdk1 and Rad54 was diminished |
| 23095053 | S100A6 depletion caused a decrease in both cyclin-dependent kinase 1 (CDK1) and phospho-CDK1 levels, which are essential for eukaryote cell-cycle progression |
| 23095053 | S100A6 depletion also decreased expression of CDK1, cyclin A1 (CCNA1) and cyclin B (CCNB1) genes with effects on cell-cycle progression |
| 22945332 | In our efforts to elucidate key molecular pathways underlying TCS and cell cycle escape, we have previously shown that the deregulation of mitotic kinase Cdk1 and its downstream effectors are important mediators of survival and cell cycle reentry |
| 22945332 | We now report that aberrant expression of Cdk1 interferes with apoptosis and promotes the formation of polyploid senescent cells during TCS |
| 11602203 | In addition, senescence is associated with increased binding of the cyclin-dependent kinase inhibitor (CDK-I) p16(INK4a) to CDK4, down-regulation of cyclin E protein levels (and consequent loss of cyclin E/CDK2 activity), underphosphorylation of the retinoblastoma protein RB and subsequent increased levels of E2F4-RB repressive complexes |
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