HCSGD entry for CUL7

1. General information

Official gene symbolCUL7
Entrez ID9820
Gene full namecullin 7
Other gene symbolsKIAA0076 dJ20C7.5
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001570VasculogenesisISSbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005680Anaphase-promoting complexNAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006508ProteolysisNASbiological_process
GO:0006511Ubiquitin-dependent protein catabolic processIEAbiological_process
GO:0006987Activation of signaling protein activity involved in unfolded protein responseTASbiological_process
GO:0007030Golgi organizationISSbiological_process
GO:0016032Viral processIEAbiological_process
GO:0016567Protein ubiquitinationIEAbiological_process
GO:0030968Endoplasmic reticulum unfolded protein responseTASbiological_process
GO:0031467Cul7-RING ubiquitin ligase complexIDAcellular_component
GO:0031625Ubiquitin protein ligase bindingIEAmolecular_function
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0050775Positive regulation of dendrite morphogenesisIGI ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.39307320770.38681838080.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1785450232
GSE13712_SHEARDown-0.4522229367
GSE13712_STATICDown-0.3006332316
GSE19018Up0.1681053330
GSE19899_A1Down-0.1159632031
GSE19899_A2Up0.1646929145
PubMed_21979375_A1Up0.1536595154
PubMed_21979375_A2Up0.5790315679
GSE35957Down-0.1907398102
GSE36640Down-0.0047761952
GSE54402Up0.1394186943
GSE9593Down-0.2562192434
GSE43922Down-0.2393054115
GSE24585Up0.2344965473
GSE37065Down-0.3582466163
GSE28863_A1Up0.3008981293
GSE28863_A2Up0.5510061592
GSE28863_A3Up0.0688603072
GSE28863_A4Down-0.0324937258
GSE48662Up0.5078692780

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017662MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

18498745In this report, we identified insulin receptor substrate 1 (IRS-1), a critical mediator of the insulin/insulin-like growth factor 1 signaling, as a proteolytic target of the CUL7 E3 ligase in a manner that depends on mammalian target of rapamycin and the p70 S6 kinase activities
18498745Interestingly, while embryonic fibroblasts of Cul7-/- mice were found to accumulate IRS-1 and exhibit increased activation of IRS-1's downstream Akt and MEK/ERK pathways, these null cells grew poorly and displayed phenotypes reminiscent of those associated with oncogene-induced senescence
18498745Taken together, our findings demonstrate a key role for the CUL7 E3 in targeting IRS-1 for degradation, a process that may contribute to the regulation of cellular senescence
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