HCSGD entry for CCP110
1. General information
| Official gene symbol | CCP110 |
|---|---|
| Entrez ID | 9738 |
| Gene full name | centriolar coiled coil protein 110kDa |
| Other gene symbols | CP110 Cep110 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000086 | G2/M transition of mitotic cell cycle | TAS | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0005814 | Centriole | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0007099 | Centriole replication | IMP | biological_process |
| GO:0030030 | Cell projection organization | IEA | biological_process |
| GO:0032465 | Regulation of cytokinesis | IMP | biological_process |
| GO:0051298 | Centrosome duplication | IDA IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4338361308 | 0.1077863379 | 0.9999902473 | 0.6282205934 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2615667111 |
| GSE13712_SHEAR | Down | -0.1080564419 |
| GSE13712_STATIC | Down | -0.1030418417 |
| GSE19018 | Down | -0.0737169360 |
| GSE19899_A1 | Up | 0.0200323872 |
| GSE19899_A2 | Down | -0.6542599917 |
| PubMed_21979375_A1 | Down | -0.0463641133 |
| PubMed_21979375_A2 | Down | -0.6729364829 |
| GSE35957 | Down | -0.4964464078 |
| GSE36640 | Down | -1.0864209628 |
| GSE54402 | Down | -0.0552750957 |
| GSE9593 | Down | -0.4515091792 |
| GSE43922 | Up | 0.0366091433 |
| GSE24585 | Up | 0.2319054400 |
| GSE37065 | Up | 0.1172582211 |
| GSE28863_A1 | Up | 0.6960551238 |
| GSE28863_A2 | Up | 0.7735197145 |
| GSE28863_A3 | Up | 0.3750274751 |
| GSE28863_A4 | Up | 0.2105666316 |
| GSE48662 | Down | -0.3466507285 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-129-2-3p | MIMAT0004605 | MIRT006725 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 22684256 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016275 | Microarray | Functional MTI (Weak) | 20304954 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25486364 | Levels of the negative ciliary regulator CP110 were reduced in senescent cells, as were levels of key elements of the Hedgehog pathway |
| 25486364 | Depletion of CP110 in young cell populations increased ciliation frequencies and reduced cell proliferation |
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