HCSGD entry for VPRBP
1. General information
| Official gene symbol | VPRBP |
|---|---|
| Entrez ID | 9730 |
| Gene full name | Vpr (HIV-1) binding protein |
| Other gene symbols | DCAF1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0008180 | COP9 signalosome | IDA | cellular_component |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0016567 | Protein ubiquitination | IEA | biological_process |
| GO:0030183 | B cell differentiation | ISS | biological_process |
| GO:0033151 | V(D)J recombination | ISS | biological_process |
| GO:0035212 | Cell competition in a multicellular organism | IMP | biological_process |
| GO:1990244 | Histone kinase activity (H2A-T120 specific) | IDA | molecular_function |
| GO:1990245 | Histone H2A-T120 phosphorylation | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4082211960 | 0.4576062650 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0801875988 |
| GSE13712_SHEAR | Up | 0.0930530958 |
| GSE13712_STATIC | Up | 0.0369567384 |
| GSE19018 | Down | -0.2403396503 |
| GSE19899_A1 | Down | -0.0145916801 |
| GSE19899_A2 | Up | 0.1116126579 |
| PubMed_21979375_A1 | Down | -0.5601543103 |
| PubMed_21979375_A2 | Up | 0.3312196032 |
| GSE35957 | Down | -0.1722005825 |
| GSE36640 | Down | -0.8382249761 |
| GSE54402 | Up | 0.3490184021 |
| GSE9593 | Down | -0.0189742439 |
| GSE43922 | Up | 0.1698233309 |
| GSE24585 | Down | -0.2419500054 |
| GSE37065 | Up | 0.1979019933 |
| GSE28863_A1 | Up | 0.4334101929 |
| GSE28863_A2 | Up | 0.4281079313 |
| GSE28863_A3 | Down | -0.5819023941 |
| GSE28863_A4 | Down | -0.1596085609 |
| GSE48662 | Up | 0.0064618113 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-484 | MIMAT0002174 | MIRT042061 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050949 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23612978 | As a molecular adaptor, Vpr enhanced the interaction between TERT and the VPRBP substrate receptor of the DYRK2-associated EDD-DDB1-VPRBP E3 ligase complex, resulting in increased ubiquitination of TERT |
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