HCSGD entry for RAPGEF2

1. General information

Official gene symbolRAPGEF2
Entrez ID9693
Gene full nameRap guanine nucleotide exchange factor (GEF) 2
Other gene symbolsCNrasGEF NRAPGEP PDZ-GEF1 PDZGEF1 RA-GEF Rap-GEP nRap GEP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000165MAPK cascadeNASbiological_process
GO:0001568Blood vessel developmentISSbiological_process
GO:0001764Neuron migrationISSbiological_process
GO:0004871Signal transducer activityTASmolecular_function
GO:0005085Guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0005088Ras guanyl-nucleotide exchange factor activityIDAmolecular_function
GO:0005509Calcium ion bindingNASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005622IntracellularIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005770Late endosomeIDAcellular_component
GO:0005886Plasma membraneIEA ISScellular_component
GO:0005887Integral component of plasma membraneNAScellular_component
GO:0005911Cell-cell junctionISScellular_component
GO:0007186G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0007218Neuropeptide signaling pathwayIDAbiological_process
GO:0007264Small GTPase mediated signal transductionIEA TASbiological_process
GO:0008285Negative regulation of cell proliferationIDAbiological_process
GO:0010976Positive regulation of neuron projection developmentIEA ISSbiological_process
GO:0016020MembraneIDAcellular_component
GO:0017034Rap guanyl-nucleotide exchange factor activityIDA IMPmolecular_function
GO:0019901Protein kinase bindingIEAmolecular_function
GO:0019933CAMP-mediated signalingIDA NASbiological_process
GO:0019992Diacylglycerol bindingNASmolecular_function
GO:0021591Ventricular system developmentISSbiological_process
GO:0021884Forebrain neuron developmentISSbiological_process
GO:0030165PDZ domain bindingIDAmolecular_function
GO:0030552CAMP bindingIDAmolecular_function
GO:0030553CGMP bindingIDAmolecular_function
GO:0031175Neuron projection developmentIDAbiological_process
GO:0031547Brain-derived neurotrophic factor receptor signaling pathwayIEA ISSbiological_process
GO:0031697Beta-1 adrenergic receptor bindingIDAmolecular_function
GO:0032092Positive regulation of protein bindingISSbiological_process
GO:0032320Positive regulation of Ras GTPase activityIDAbiological_process
GO:0032486Rap protein signal transductionIMPbiological_process
GO:0032854Positive regulation of Rap GTPase activityIDA IEA IMPbiological_process
GO:0035556Intracellular signal transductionTASbiological_process
GO:0038180Nerve growth factor signaling pathwayIEA ISSbiological_process
GO:0043005Neuron projectionIEA ISScellular_component
GO:0043025Neuronal cell bodyIEA ISScellular_component
GO:0043234Protein complexIEA ISScellular_component
GO:0043950Positive regulation of cAMP-mediated signalingIDAbiological_process
GO:0045202SynapseIEA ISScellular_component
GO:0045860Positive regulation of protein kinase activityIDAbiological_process
GO:0046582Rap GTPase activator activityIDAmolecular_function
GO:0048022Negative regulation of melanin biosynthetic processISSbiological_process
GO:0048167Regulation of synaptic plasticityIEA ISSbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0050699WW domain bindingIDAmolecular_function
GO:0050774Negative regulation of dendrite morphogenesisIDAbiological_process
GO:0061028Establishment of endothelial barrierIMPbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIDAbiological_process
GO:0071320Cellular response to cAMPIDAbiological_process
GO:0071321Cellular response to cGMPIDAbiological_process
GO:0071880Adenylate cyclase-activating adrenergic receptor signaling pathwayIDAbiological_process
GO:1901888Regulation of cell junction assemblyIMPbiological_process
GO:1990090Cellular response to nerve growth factor stimulusISSbiological_process
GO:2000481Positive regulation of cAMP-dependent protein kinase activityIDAbiological_process
GO:2000670Positive regulation of dendritic cell apoptotic processIDAbiological_process
GO:2001214Positive regulation of vasculogenesisISSbiological_process
GO:2001224Positive regulation of neuron migrationISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.36619625770.11811227920.99999024730.6601466667

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0665878302
GSE13712_SHEARUp0.3244666514
GSE13712_STATICUp0.3051946093
GSE19018Up0.1339503325
GSE19899_A1Down-0.3136528373
GSE19899_A2Down-0.5010299889
PubMed_21979375_A1Down-0.5069377318
PubMed_21979375_A2Down-0.2003123745
GSE35957Down-0.0289078007
GSE36640Up0.4714263509
GSE54402Down-0.7218426564
GSE9593Up0.0895758151
GSE43922Down-0.4907160043
GSE24585Up0.0157534011
GSE37065Up0.3793279406
GSE28863_A1Up0.3346180800
GSE28863_A2Up0.7995069538
GSE28863_A3Down-0.7104766302
GSE28863_A4Down-0.2847597563
GSE48662Up0.1944027758

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017869MicroarrayFunctional MTI (Weak)18185580
hsa-miR-155-5pMIMAT0000646MIRT020791Reporter assay;OtherFunctional MTI20584899
hsa-miR-1MIMAT0000416MIRT023803MicroarrayFunctional MTI (Weak)18668037
hsa-miR-615-3pMIMAT0003283MIRT039795CLASHFunctional MTI (Weak)23622248
hsa-miR-149-5pMIMAT0000450MIRT045434CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.