HCSGD entry for MDC1
1. General information
| Official gene symbol | MDC1 |
|---|---|
| Entrez ID | 9656 |
| Gene full name | mediator of DNA-damage checkpoint 1 |
| Other gene symbols | NFBD1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000724 | Double-strand break repair via homologous recombination | TAS | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005694 | Chromosome | IEA ISS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005925 | Focal adhesion | IDA | cellular_component |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0006302 | Double-strand break repair | TAS | biological_process |
| GO:0008022 | Protein C-terminus binding | IPI | molecular_function |
| GO:0031573 | Intra-S DNA damage checkpoint | TAS | biological_process |
| GO:0070975 | FHA domain binding | IPI | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9654679685 | 0.0077915771 | 0.9999902473 | 0.1764906196 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2415851633 |
| GSE13712_SHEAR | Up | 0.0593768807 |
| GSE13712_STATIC | Down | -0.4902579757 |
| GSE19018 | Down | -0.2125893782 |
| GSE19899_A1 | Down | -0.3091539350 |
| GSE19899_A2 | Down | -1.2825441076 |
| PubMed_21979375_A1 | Down | -0.8815868367 |
| PubMed_21979375_A2 | Down | -0.8487230940 |
| GSE35957 | Down | -1.0008852995 |
| GSE36640 | Down | -1.3680861764 |
| GSE54402 | Down | -0.0566193322 |
| GSE9593 | Down | -0.6014601395 |
| GSE43922 | Down | -0.4175056744 |
| GSE24585 | Down | -0.1758115040 |
| GSE37065 | Down | -0.0397608481 |
| GSE28863_A1 | Up | 0.3563142098 |
| GSE28863_A2 | Up | 0.7599443264 |
| GSE28863_A3 | Up | 0.1504719445 |
| GSE28863_A4 | Down | -0.1299487249 |
| GSE48662 | Down | -0.2471947447 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT023516 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024535 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT036863 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040462 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040912 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-505-3p | MIMAT0002876 | MIRT041049 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043058 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-361-5p | MIMAT0000703 | MIRT044086 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-5p | MIMAT0000072 | MIRT050697 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-3p | MIMAT0000071 | MIRT050762 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21408175 | Using combined immunofluorescence and telomere-fluorescence in-situ hybridization we show that gammaH2AX-foci co-localize consistently with other repair factors such as pATM, MDC1 and 53BP1, but not significantly with telomeres, strongly supporting the telomere-independent origin for the majority of foci |
| 21118958 | Importantly, depletion of the DNA-SCARS-stabilizing component histone H2AX did not deplete 53BP1 from DNA-SCARS but diminished the presence of MDC1 and activated CHK2 |
| 18001825 | We have shown that RNF8 facilitates the accumulation of checkpoint mediator proteins BRCA1 and 53BP1 to the damaged chromatin, on one hand through the phospho-dependent FHA domain-mediated binding of RNF8 to MDC1, on the other hand via its role in ubiquitylating H2AX and possibly other substrates at damage sites |
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