HCSGD entry for SOCS5
1. General information
| Official gene symbol | SOCS5 |
|---|---|
| Entrez ID | 9655 |
| Gene full name | suppressor of cytokine signaling 5 |
| Other gene symbols | CIS6 CISH6 Cish5 SOCS-5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005154 | Epidermal growth factor receptor binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | IEA | biological_process |
| GO:0007175 | Negative regulation of epidermal growth factor-activated receptor activity | IDA | biological_process |
| GO:0007259 | JAK-STAT cascade | IEA | biological_process |
| GO:0009968 | Negative regulation of signal transduction | NAS | biological_process |
| GO:0016049 | Cell growth | NAS | biological_process |
| GO:0016567 | Protein ubiquitination | IEA | biological_process |
| GO:0019221 | Cytokine-mediated signaling pathway | ISS | biological_process |
| GO:0030971 | Receptor tyrosine kinase binding | IPI | molecular_function |
| GO:0032436 | Positive regulation of proteasomal ubiquitin-dependent protein catabolic process | IMP | biological_process |
| GO:0040008 | Regulation of growth | IEA | biological_process |
| GO:0045627 | Positive regulation of T-helper 1 cell differentiation | ISS | biological_process |
| GO:0045629 | Negative regulation of T-helper 2 cell differentiation | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9648741461 | 0.0060411117 | 0.9999902473 | 0.1575897919 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1696343784 |
| GSE13712_SHEAR | Down | -0.2524080478 |
| GSE13712_STATIC | Down | -0.0178532038 |
| GSE19018 | Down | -0.4942228199 |
| GSE19899_A1 | Down | -1.4351821152 |
| GSE19899_A2 | Down | -0.8518525876 |
| PubMed_21979375_A1 | Down | -1.3340527633 |
| PubMed_21979375_A2 | Down | -1.4645173087 |
| GSE35957 | Up | 0.0729950457 |
| GSE36640 | Up | 0.2921673242 |
| GSE54402 | Down | -0.7051664952 |
| GSE9593 | Up | 0.0274168634 |
| GSE43922 | Down | -0.7227940242 |
| GSE24585 | Down | -0.2941119812 |
| GSE37065 | Down | -0.1125302011 |
| GSE28863_A1 | Up | 0.4410539146 |
| GSE28863_A2 | Up | 0.2701453735 |
| GSE28863_A3 | Up | 0.0559820617 |
| GSE28863_A4 | Down | -0.1029666359 |
| GSE48662 | Down | -0.5804269045 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | MIRT002412 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-9-5p | MIMAT0000441 | MIRT007035 | Luciferase reporter assay | Functional MTI | 22773185 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051149 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | NA | hsa-miR-21 | 17991735 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
