HCSGD entry for IKBKE

1. General information

Official gene symbolIKBKE
Entrez ID9641
Gene full nameinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
Other gene symbolsIKK-E IKK-i IKKE IKKI
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0004672Protein kinase activityTASmolecular_function
GO:0004704NF-kappaB-inducing kinase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0006955Immune responseNASbiological_process
GO:0008384IkappaB kinase activityIEAmolecular_function
GO:0008630Intrinsic apoptotic signaling pathway in response to DNA damageIMPbiological_process
GO:0010008Endosome membraneTAScellular_component
GO:0016605PML bodyIDAcellular_component
GO:0023014Signal transduction by phosphorylationIDAbiological_process
GO:0032480Negative regulation of type I interferon productionTASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0038061NIK/NF-kappaB signalingIDAbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIEPbiological_process
GO:0045087Innate immune responseTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.24936809010.67959665290.93806103171.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1504691798
GSE13712_SHEARDown-0.2501048631
GSE13712_STATICDown-0.1268479612
GSE19018Up0.0764851939
GSE19899_A1Down-0.0975717674
GSE19899_A2Up0.4642131083
PubMed_21979375_A1Up0.6081025233
PubMed_21979375_A2Up0.6483387174
GSE35957Down-0.1942400565
GSE36640Down-0.1006099734
GSE54402Up0.3327299045
GSE9593Up0.1387721561
GSE43922Up0.0878254439
GSE24585Down-0.3744515798
GSE37065Up0.2670587768
GSE28863_A1Up0.1433039825
GSE28863_A2Up0.2596964994
GSE28863_A3Down-0.1652975537
GSE28863_A4Down-0.0080484989
GSE48662Down-0.0225178070

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-296-5pMIMAT0000690MIRT006572Luciferase reporter assayFunctional MTI22114321
hsa-miR-155-5pMIMAT0000646MIRT003484qRT-PCR//Western blotFunctional MTI18753206
hsa-miR-155-5pMIMAT0000646MIRT003484Luciferase reporter assayFunctional MTI19177201
hsa-miR-155-5pMIMAT0000646MIRT003484ProteomicsFunctional MTI (Weak)20584899
hsa-miR-124-3pMIMAT0000422MIRT022344MicroarrayFunctional MTI (Weak)18668037
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-155-5pMIMAT0000646NAhsa-miR-155{Western blot}{overexpression by miRNA mimics tranfection}19650740
hsa-miR-296-5pMIMAT00006901hsa-miR-29622114321
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25594009TBK1 knock-down, or treatment with TBK1-II, a drug that efficiently inhibits TBK1 and its close relative IKKepsilon (IKBKE), suppressed growth of human HER2(+) BC cells and induced cellular senescence
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