HCSGD entry for ISG15

1. General information

Official gene symbolISG15
Entrez ID9636
Gene full nameISG15 ubiquitin-like modifier
Other gene symbolsG1P2 IFI15 IP17 UCRP hUCRP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0016032Viral processIEAbiological_process
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0019941Modification-dependent protein catabolic processIEAbiological_process
GO:0031386Protein tagIEAmolecular_function
GO:0031397Negative regulation of protein ubiquitinationIDAbiological_process
GO:0032020ISG15-protein conjugationIDA IMPbiological_process
GO:0032480Negative regulation of type I interferon productionTASbiological_process
GO:0032649Regulation of interferon-gamma productionIMPbiological_process
GO:0034340Response to type I interferonIDAbiological_process
GO:0042742Defense response to bacteriumIMPbiological_process
GO:0045071Negative regulation of viral genome replicationIMPbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045648Positive regulation of erythrocyte differentiationIEAbiological_process
GO:0051607Defense response to virusIMPbiological_process
GO:0060337Type I interferon signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00206930970.32291791350.12267184681.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up1.2517777191
GSE13712_SHEARUp3.3560376103
GSE13712_STATICUp2.0425034214
GSE19018Up0.3050553036
GSE19899_A1Down-0.3362859815
GSE19899_A2Up0.5243681952
PubMed_21979375_A1Down-1.4568836649
PubMed_21979375_A2Down-0.3148909917
GSE35957Down-3.2537735518
GSE36640Up2.1398017232
GSE54402Up0.0093776538
GSE9593Up0.0137197294
GSE43922Up0.1298295093
GSE24585Up1.1847266656
GSE37065Up0.8039264693
GSE28863_A1Down-0.2996914749
GSE28863_A2Up0.1004200779
GSE28863_A3Up0.2984214719
GSE28863_A4Down-0.0037438114
GSE48662Up0.5945273796

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-146a-5pMIMAT0000449MIRT021235MicroarrayFunctional MTI (Weak)18057241
hsa-miR-1MIMAT0000416MIRT023954MicroarrayFunctional MTI (Weak)18668037
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

19802007Here, we show that genotoxic drugs capable of inducing premature senescence in normal and cancer cells, such as 5-bromo-2'-deoxyuridine (BrdU), distamycin A (DMA), aphidicolin and hydroxyurea, persistently activate Janus kinase-signal transducer and activator of transcription (JAK/STAT) signaling and expression of interferon-stimulated genes (ISGs), such as MX1, OAS, ISG15, STAT1, PML, IRF1 and IRF7, in several human cancer cell lines
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