HCSGD entry for CLCA2
1. General information
| Official gene symbol | CLCA2 |
|---|---|
| Entrez ID | 9635 |
| Gene full name | chloride channel accessory 2 |
| Other gene symbols | CACC CACC3 CLCRG2 CaCC-3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005254 | Chloride channel activity | IEA | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006810 | Transport | TAS | biological_process |
| GO:0007155 | Cell adhesion | IEA | biological_process |
| GO:0009925 | Basal plasma membrane | IEA | cellular_component |
| GO:0015276 | Ligand-gated ion channel activity | IEA | molecular_function |
| GO:0030054 | Cell junction | IEA | cellular_component |
| GO:0034220 | Ion transmembrane transport | TAS | biological_process |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
| GO:1902476 | Chloride transmembrane transport | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0215363474 | 0.9833130770 | 0.3534028678 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3695601952 |
| GSE13712_SHEAR | Down | -0.1343531265 |
| GSE13712_STATIC | Down | -0.0335866538 |
| GSE19018 | Up | 0.0703481363 |
| GSE19899_A1 | Up | 0.1493616071 |
| GSE19899_A2 | Up | 0.2424158268 |
| PubMed_21979375_A1 | Up | 0.1381914985 |
| PubMed_21979375_A2 | Up | 0.3027222757 |
| GSE35957 | Up | 0.1366597617 |
| GSE36640 | Up | 0.6178382120 |
| GSE54402 | Up | 0.0081067487 |
| GSE9593 | Up | 0.4679076791 |
| GSE43922 | Up | 0.5925795993 |
| GSE24585 | Up | 0.0928866898 |
| GSE37065 | Up | 0.5042199672 |
| GSE28863_A1 | Up | 0.0715997064 |
| GSE28863_A2 | Up | 1.3564136841 |
| GSE28863_A3 | Up | 0.0313446022 |
| GSE28863_A4 | Up | 0.0563202427 |
| GSE48662 | Up | 0.0398082106 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7b-5p | MIMAT0000063 | MIRT051890 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22431922 | CLCA2 as a p53-inducible senescence mediator |
| 22431922 | Through the screening of two genome-wide expression profile data sets, one for cells in which exogenous p53 was introduced and the other for senescent fibroblasts, we have identified chloride channel accessory 2 (CLCA2) as a p53-inducible senescence-associated gene |
| 22431922 | CLCA2 was remarkably induced by replicative senescence as well as oxidative stress in a p53-dependent manner |
| 22431922 | We also found that ectopically expressed CLCA2 induced cellular senescence, and the down-regulation of CLCA2 by small interfering RNA caused inhibition of oxidative stress-induced senescence |
| 22431922 | Interestingly, the reduced expression of CLCA2 was frequently observed in various kinds of cancers including prostate cancer, whereas its expression was not affected in precancerous prostatic intraepithelial neoplasia |
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