HCSGD entry for ABCG1

1. General information

Official gene symbol	ABCG1
Entrez ID	9619
Gene full name	ATP-binding cassette, sub-family G (WHITE), member 1
Other gene symbols	ABC8 WHITE1
Links to Entrez Gene	Links to Entrez Gene

2. Neighbors in the network

This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID	GO term	Evidence	Category
GO:0000139	Golgi membrane	IEA	cellular_component
GO:0005515	Protein binding	IPI	molecular_function
GO:0005524	ATP binding	IDA IEA	molecular_function
GO:0005543	Phospholipid binding	IC	molecular_function
GO:0005548	Phospholipid transporter activity	IDA	molecular_function
GO:0005739	Mitochondrion	IDA	cellular_component
GO:0005768	Endosome	ISS	cellular_component
GO:0005789	Endoplasmic reticulum membrane	IEA	cellular_component
GO:0005794	Golgi apparatus	IDA	cellular_component
GO:0005886	Plasma membrane	IDA TAS	cellular_component
GO:0005887	Integral component of plasma membrane	IC	cellular_component
GO:0006200	ATP catabolic process	IDA	biological_process
GO:0006355	Regulation of transcription, DNA-templated	ISS	biological_process
GO:0006810	Transport	IEA	biological_process
GO:0008203	Cholesterol metabolic process	IDA	biological_process
GO:0009720	Detection of hormone stimulus	NAS	biological_process
GO:0009897	External side of plasma membrane	IDA	cellular_component
GO:0010033	Response to organic substance	IDA	biological_process
GO:0010745	Negative regulation of macrophage derived foam cell differentiation	TAS	biological_process
GO:0010872	Regulation of cholesterol esterification	ISS	biological_process
GO:0010875	Positive regulation of cholesterol efflux	IEA	biological_process
GO:0010887	Negative regulation of cholesterol storage	TAS	biological_process
GO:0015485	Cholesterol binding	IC	molecular_function
GO:0016020	Membrane	IEA	cellular_component
GO:0016887	ATPase activity	IEA	molecular_function
GO:0017127	Cholesterol transporter activity	IDA TAS	molecular_function
GO:0019534	Toxin transporter activity	IDA	molecular_function
GO:0032367	Intracellular cholesterol transport	IMP	biological_process
GO:0033344	Cholesterol efflux	IDA	biological_process
GO:0033700	Phospholipid efflux	IMP	biological_process
GO:0033993	Response to lipid	IDA	biological_process
GO:0034041	Sterol-transporting ATPase activity	IDA	molecular_function
GO:0034374	Low-density lipoprotein particle remodeling	ISS	biological_process
GO:0034375	High-density lipoprotein particle remodeling	ISS	biological_process
GO:0034436	Glycoprotein transport	IDA	biological_process
GO:0034437	Glycoprotein transporter activity	IDA	molecular_function
GO:0042157	Lipoprotein metabolic process	TAS	biological_process
GO:0042632	Cholesterol homeostasis	IDA	biological_process
GO:0042803	Protein homodimerization activity	IDA	molecular_function
GO:0042987	Amyloid precursor protein catabolic process	IDA	biological_process
GO:0043531	ADP binding	IDA	molecular_function
GO:0043691	Reverse cholesterol transport	ISS	biological_process
GO:0044281	Small molecule metabolic process	TAS	biological_process
GO:0045542	Positive regulation of cholesterol biosynthetic process	ISS	biological_process
GO:0046982	Protein heterodimerization activity	IPI	molecular_function
GO:0046983	Protein dimerization activity	NAS	molecular_function
GO:0055037	Recycling endosome	ISS	cellular_component
GO:0055085	Transmembrane transport	TAS	biological_process
GO:0055091	Phospholipid homeostasis	IMP	biological_process
GO:0055099	Response to high density lipoprotein particle	IEA	biological_process
GO:1901998	Toxin transport	IDA	biological_process

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4. Expression levels in datasets

Meta-analysis result

p-value up	p-value down	FDR up	FDR down
0.0040613465	0.9900673265	0.1718954984	1.0000000000

Individual experiment result
( "-" represent NA in the specific microarray platform )

Data source	Up or down	Log fold change
GSE11954	Up	0.1423571937
GSE13712_SHEAR	Up	0.0966256325
GSE13712_STATIC	Up	0.4928157665
GSE19018	Up	0.4597246978
GSE19899_A1	Up	0.3943814570
GSE19899_A2	Up	1.2628648451
PubMed_21979375_A1	Up	1.3519866787
PubMed_21979375_A2	Up	1.7488656673
GSE35957	Down	-0.0680024146
GSE36640	Down	-0.9132943597
GSE54402	Up	0.7052134869
GSE9593	Up	0.1211195718
GSE43922	Up	0.9975927377
GSE24585	Up	0.1332707349
GSE37065	Up	0.0789010677
GSE28863_A1	Down	-0.0494049663
GSE28863_A2	Down	-0.0820085669
GSE28863_A3	Up	0.3270574479
GSE28863_A4	Up	0.1502420943
GSE48662	Up	0.6026841522

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Not regulated by compounds

Drugs

Name	Drug	Accession number
Adenosine triphosphate	DB00171	NUTR00017 \| EXPT00007

MicroRNAs

mirTarBase

No target information from mirTarBase

mirRecord

No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

1.General information
2.Neighbors in the network
3.Gene Ontology Annotation
4.Expression levels
5.Regulation
6.Text-mining results

HCSGD entry for ABCG1

1. General information

2. Neighbors in the network

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

4. Expression levels in datasets

Meta-analysis result

Individual experiment result ( "-" represent NA in the specific microarray platform )

( "-" represent NA in the specific microarray platform )

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Drugs

Name

Drug

Accession number

MicroRNAs

mirTarBase

mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

Individual experiment result
( "-" represent NA in the specific microarray platform )