HCSGD entry for TRAF4
1. General information
| Official gene symbol | TRAF4 |
|---|---|
| Entrez ID | 9618 |
| Gene full name | TNF receptor-associated factor 4 |
| Other gene symbols | CART1 MLN62 RNF83 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | TAS | molecular_function |
| GO:0004842 | Ubiquitin-protein ligase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005856 | Cytoskeleton | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0005923 | Tight junction | IEA | cellular_component |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0007165 | Signal transduction | IEA | biological_process |
| GO:0007585 | Respiratory gaseous exchange | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0019901 | Protein kinase binding | IEA | molecular_function |
| GO:0030323 | Respiratory tube development | IEA | biological_process |
| GO:0031625 | Ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0031996 | Thioesterase binding | IPI | molecular_function |
| GO:0042981 | Regulation of apoptotic process | IEA | biological_process |
| GO:0045860 | Positive regulation of protein kinase activity | IDA | biological_process |
| GO:0046330 | Positive regulation of JNK cascade | IDA | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0050699 | WW domain binding | IPI | molecular_function |
| GO:0090073 | Positive regulation of protein homodimerization activity | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1125835303 | 0.8959348467 | 0.6916810401 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2141002085 |
| GSE13712_SHEAR | Down | -0.0496695458 |
| GSE13712_STATIC | Up | 0.1260054056 |
| GSE19018 | Down | -0.0216148797 |
| GSE19899_A1 | Up | 0.0944963984 |
| GSE19899_A2 | Up | 0.8372408597 |
| PubMed_21979375_A1 | Up | 0.4927168147 |
| PubMed_21979375_A2 | Up | 0.5442938408 |
| GSE35957 | Up | 0.1269222169 |
| GSE36640 | Up | 0.3074702560 |
| GSE54402 | Up | 0.1503234299 |
| GSE9593 | Up | 0.0152060904 |
| GSE43922 | Up | 0.5487498843 |
| GSE24585 | Down | -0.0087128433 |
| GSE37065 | Down | -0.0406073509 |
| GSE28863_A1 | Down | -0.4496525282 |
| GSE28863_A2 | Down | -0.2485427127 |
| GSE28863_A3 | Down | -0.2121694789 |
| GSE28863_A4 | Up | 0.1186900605 |
| GSE48662 | Up | 0.1943577236 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-605-5p | MIMAT0003273 | MIRT040479 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044793 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT046838 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT047104 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049070 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051252 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-4284 | MIMAT0016915 | MIRT052844 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
