HCSGD entry for NCOR1

1. General information

Official gene symbolNCOR1
Entrez ID9611
Gene full namenuclear receptor corepressor 1
Other gene symbolsN-CoR N-CoR1 TRAC1 hN-CoR
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000118Histone deacetylase complexIDAcellular_component
GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEA IMP TASbiological_process
GO:0000790Nuclear chromatinIDAcellular_component
GO:0001102RNA polymerase II activating transcription factor bindingIPImolecular_function
GO:0002361CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiationIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0003714Transcription corepressor activityIDA IEA IMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIC IDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005667Transcription factor complexIEAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0005876Spindle microtubuleIDAcellular_component
GO:0006351Transcription, DNA-templatedTASbiological_process
GO:0006366Transcription from RNA polymerase II promoterTASbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayTASbiological_process
GO:0007219Notch signaling pathwayTASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0014067Negative regulation of phosphatidylinositol 3-kinase signalingIEAbiological_process
GO:0016568Chromatin modificationIEAbiological_process
GO:0016580Sin3 complexIDAcellular_component
GO:0017053Transcriptional repressor complexIDA IEAcellular_component
GO:0021794Thalamus developmentIEAbiological_process
GO:0031065Positive regulation of histone deacetylationIEAbiological_process
GO:0032922Circadian regulation of gene expressionIEAbiological_process
GO:0035033Histone deacetylase regulator activityIEAmolecular_function
GO:0040014Regulation of multicellular organism growthIEAbiological_process
GO:0042632Cholesterol homeostasisIEAbiological_process
GO:0042826Histone deacetylase bindingIPImolecular_function
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0044212Transcription regulatory region DNA bindingISSmolecular_function
GO:0044255Cellular lipid metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046329Negative regulation of JNK cascadeIDAbiological_process
GO:0046965Retinoid X receptor bindingIEAmolecular_function
GO:0046966Thyroid hormone receptor bindingIEAmolecular_function
GO:0051225Spindle assemblyIMPbiological_process
GO:0060318Definitive erythrocyte differentiationIEAbiological_process
GO:0072362Regulation of glycolysis by negative regulation of transcription from RNA polymerase II promoterIMPbiological_process
GO:0072368Regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoterIMPbiological_process
GO:2000191Regulation of fatty acid transportICbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.38213431100.50998566160.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2283169538
GSE13712_SHEARDown-0.0369571772
GSE13712_STATICUp0.0311918214
GSE19018Up0.0756461050
GSE19899_A1Down-0.1101753763
GSE19899_A2Down-0.3286659716
PubMed_21979375_A1Down-0.4591443579
PubMed_21979375_A2Down-0.0351040599
GSE35957Down-0.1298250675
GSE36640Down-0.4393583383
GSE54402Up0.0431171003
GSE9593Up0.0899157175
GSE43922Down-0.0384790297
GSE24585Up0.3024837742
GSE37065Up0.0389182855
GSE28863_A1Up0.9768146105
GSE28863_A2Up0.2068025072
GSE28863_A3Up0.1628858637
GSE28863_A4Up0.2222580268
GSE48662Up0.0961027667

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1301-3pMIMAT0005797MIRT036031CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT040375CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT041973CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044744CLASHFunctional MTI (Weak)23622248
hsa-let-7b-5pMIMAT0000063MIRT052038CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.