HCSGD entry for CD47
1. General information
| Official gene symbol | CD47 |
|---|---|
| Entrez ID | 961 |
| Gene full name | CD47 molecule |
| Other gene symbols | IAP MER6 OA3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | IEA | cellular_component |
| GO:0007155 | Cell adhesion | IEA | biological_process |
| GO:0007229 | Integrin-mediated signaling pathway | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008228 | Opsonization | IEA | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IDA | biological_process |
| GO:0009617 | Response to bacterium | IEA | biological_process |
| GO:0022409 | Positive regulation of cell-cell adhesion | IDA | biological_process |
| GO:0050729 | Positive regulation of inflammatory response | IEA | biological_process |
| GO:0050766 | Positive regulation of phagocytosis | IEA | biological_process |
| GO:0050870 | Positive regulation of T cell activation | IDA | biological_process |
| GO:0050900 | Leukocyte migration | TAS | biological_process |
| GO:0070053 | Thrombospondin receptor activity | IPI | molecular_function |
| GO:0070062 | Extracellular vesicular exosome | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6001677824 | 0.0758695110 | 0.9999902473 | 0.5197713170 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3251986475 |
| GSE13712_SHEAR | Up | 0.0866381259 |
| GSE13712_STATIC | Up | 0.4180936439 |
| GSE19018 | Up | 0.3314953493 |
| GSE19899_A1 | Down | -0.7982388478 |
| GSE19899_A2 | Down | -0.5840435712 |
| PubMed_21979375_A1 | Down | -1.1157274592 |
| PubMed_21979375_A2 | Down | -0.6337969596 |
| GSE35957 | Up | 0.0366777044 |
| GSE36640 | Up | 0.0124761519 |
| GSE54402 | Down | -0.7232877265 |
| GSE9593 | Up | 0.4651926537 |
| GSE43922 | Down | -0.6226922818 |
| GSE24585 | Down | -0.0682541091 |
| GSE37065 | Up | 0.5130047467 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.3261357719 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | MIRT030709 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-505-3p | MIMAT0002876 | MIRT040987 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23801922 | Role of CD47 and Signal Regulatory Protein Alpha (SIRPalpha) in Regulating the Clearance of Viable or Aged Blood Cells |
| 23801922 | SUMMARY: The ubiquitously expressed cell surface glycoprotein CD47 is expressed by virtually all cells in the host, where it can function to regulate integrin-mediated responses, or constitute an important part of the erythrocyte band 3/Rh multi-protein complex |
| 23801922 | In addition, CD47 can protect viable cells from being phagocytosed by macrophages or dendritic cells |
| 23801922 | The latter mechanism is dependent on the interaction between target cell CD47 and SIRPalpha on the phagocyte |
| 23801922 | The expression level and/or distribution of CD47 may be altered on the surface of apoptotic/senescent cells, rendering the phagocytosis inhibitory function of the CD47/SIRPalpha interaction reduced or eliminated |
| 17188915 | RBC membrane molecules CD55 and CD59 along with phosphatydylserine and CD47 were measured |
| 15095782 | Clearance of RBC is not only the result of cell-bound opsonins, but is enhanced by the loss of RBC membrane constituents, such as CD47 and sialic acids |
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