HCSGD entry for PRDX6
1. General information
| Official gene symbol | PRDX6 |
|---|---|
| Entrez ID | 9588 |
| Gene full name | peroxiredoxin 6 |
| Other gene symbols | 1-Cys AOP2 NSGPx PRX aiPLA2 p29 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004602 | Glutathione peroxidase activity | IEA | molecular_function |
| GO:0004623 | Phospholipase A2 activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005764 | Lysosome | IEA | cellular_component |
| GO:0005829 | Cytosol | NAS | cellular_component |
| GO:0006979 | Response to oxidative stress | IDA | biological_process |
| GO:0009395 | Phospholipid catabolic process | IDA | biological_process |
| GO:0016023 | Cytoplasmic membrane-bounded vesicle | IEA | cellular_component |
| GO:0016209 | Antioxidant activity | NAS | molecular_function |
| GO:0042744 | Hydrogen peroxide catabolic process | IEA | biological_process |
| GO:0051920 | Peroxiredoxin activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9116579157 | 0.0178357927 | 0.9999902473 | 0.2614308463 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1758768982 |
| GSE13712_SHEAR | Down | -0.0844945241 |
| GSE13712_STATIC | Up | 0.0021957149 |
| GSE19018 | Up | 0.5646991126 |
| GSE19899_A1 | Down | -1.0210850535 |
| GSE19899_A2 | Down | -0.7243485184 |
| PubMed_21979375_A1 | Down | -1.1090254899 |
| PubMed_21979375_A2 | Down | -1.1708724248 |
| GSE35957 | Down | -0.1066059406 |
| GSE36640 | Up | 0.8147894639 |
| GSE54402 | Down | -0.6046687894 |
| GSE9593 | Down | -0.0493162994 |
| GSE43922 | Down | -0.7613874261 |
| GSE24585 | Down | -0.2112511224 |
| GSE37065 | Up | 0.0171500969 |
| GSE28863_A1 | Down | -0.0158216201 |
| GSE28863_A2 | Down | -0.1270270027 |
| GSE28863_A3 | Down | -0.4421123832 |
| GSE28863_A4 | Down | -0.2236932491 |
| GSE48662 | Down | -0.1118235132 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Isopropyl Alcohol | DB02325 | EXPT01912 | DB04402 |
| 2-(N-Morpholino)-Ethanesulfonic Acid | DB03814 | EXPT02154 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-632 | MIMAT0003302 | MIRT004940 | qRT-PCR//Western blot | Functional MTI | 17980029 |
| hsa-miR-320a | MIMAT0000510 | MIRT044389 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26794818 | RESULTS: Our findings showed that SOD1 and CCS-1 were significantly down-regulated in pre-senescent cells while CCS-1 and PRDX6 were up-regulated in senescent cells (p<0 |
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