HCSGD entry for BRE
1. General information
| Official gene symbol | BRE |
|---|---|
| Entrez ID | 9577 |
| Gene full name | brain and reproductive organ-expressed (TNFRSF1A modulator) |
| Other gene symbols | BRCC4 BRCC45 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000152 | Nuclear ubiquitin ligase complex | IDA | cellular_component |
| GO:0000268 | Peroxisome targeting sequence binding | TAS | molecular_function |
| GO:0005164 | Tumor necrosis factor receptor binding | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006302 | Double-strand break repair | IMP | biological_process |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IEP | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0010212 | Response to ionizing radiation | IMP | biological_process |
| GO:0016568 | Chromatin modification | IEA | biological_process |
| GO:0031572 | G2 DNA damage checkpoint | IMP | biological_process |
| GO:0031593 | Polyubiquitin binding | IDA | molecular_function |
| GO:0045739 | Positive regulation of DNA repair | IMP | biological_process |
| GO:0070531 | BRCA1-A complex | IDA | cellular_component |
| GO:0070552 | BRISC complex | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8039135139 | 0.0865498765 | 0.9999902473 | 0.5585358421 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1703581279 |
| GSE13712_SHEAR | Down | -0.7063365633 |
| GSE13712_STATIC | Down | -0.2544580781 |
| GSE19018 | Up | 0.1538380499 |
| GSE19899_A1 | Down | -0.6475014893 |
| GSE19899_A2 | Up | 0.0518346115 |
| PubMed_21979375_A1 | Down | -0.2771578492 |
| PubMed_21979375_A2 | Down | -0.1616762209 |
| GSE35957 | Up | 0.3342984588 |
| GSE36640 | Up | 0.1155955950 |
| GSE54402 | Down | -0.3757011006 |
| GSE9593 | Up | 0.8847601257 |
| GSE43922 | Down | -0.4264767588 |
| GSE24585 | Down | -0.5887997488 |
| GSE37065 | Down | -0.0646976949 |
| GSE28863_A1 | Up | 0.0867982849 |
| GSE28863_A2 | Up | 0.0874266605 |
| GSE28863_A3 | Down | -0.2302747851 |
| GSE28863_A4 | Down | -0.0714077154 |
| GSE48662 | Up | 0.2451362314 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022453 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27001068 | BRE plays an essential role in preventing replicative and DNA damage-induced premature senescence |
| 27001068 | The BRE gene, alias BRCC45, produces a 44 kDa protein that is normally distributed in both cytoplasm and nucleus |
| 27001068 | In this study, we used adult fibroblasts isolated from wild-type (WT) and BRE knockout (BRE(-/-)) mice to investigate the functional role of BRE in DNA repair and cellular senescence |
| 27001068 | We compared WT with BRE(-/-) fibroblasts at different cell passages and observed that the mutant fibroblasts entered replicative senescence earlier than the WT fibroblasts |
| 27001068 | With the use of gamma irradiation to induce DNA damage in fibroblasts, the percentage of SA-beta-Gal(+) cells was significantly higher in BRE(-/-) fibroblasts compared with WT cells, suggesting that BRE is also associated with DNA damage-induced premature senescence |
| 27001068 | We also demonstrated that the gamma irradiation induced gamma-H2AX foci, a DNA damage marker, persisted significantly longer in BRE(-/-) fibroblasts than in WT fibroblasts, confirming that the DNA repair process is impaired in the absence of BRE |
| 27001068 | In addition, the BRCA1-A complex recruitment and homologous recombination (HR)-dependent DNA repair process upon DNA damage were impaired in BRE(-/-) fibroblasts |
| 27001068 | Taken together, our results demonstrate a role for BRE in both replicative senescence and DNA damage-induced premature senescence |
| 27001068 | This can be attributed to BRE being required for BRCA1-A complex-driven HR DNA repair |
| 20551323 | In this study, we revealed that Bmi-1 regulates the expression of p16 by binding directly to the Bmi-1-responding element (BRE) within the p16 promoter |
| 20551323 | The BRE resided at bp -821 to -732 upstream of the p16 ATG codon |
| 20551323 | BRE alone was sufficient to allow Bmi-1-mediated regulation of the CMV promoter |
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