HCSGD entry for CLOCK
1. General information
| Official gene symbol | CLOCK |
|---|---|
| Entrez ID | 9575 |
| Gene full name | clock circadian regulator |
| Other gene symbols | KAT13D bHLHe8 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000077 | DNA damage checkpoint | IMP | biological_process |
| GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | IDA | molecular_function |
| GO:0000982 | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity | IEA ISS | molecular_function |
| GO:0001047 | Core promoter binding | ISS | molecular_function |
| GO:0001190 | RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription | IEA ISS | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | ISS | molecular_function |
| GO:0004402 | Histone acetyltransferase activity | IEA | molecular_function |
| GO:0004871 | Signal transducer activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005667 | Transcription factor complex | IEA IPI | cellular_component |
| GO:0005694 | Chromosome | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006355 | Regulation of transcription, DNA-templated | ISS | biological_process |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006366 | Transcription from RNA polymerase II promoter | ISS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007623 | Circadian rhythm | TAS | biological_process |
| GO:0009648 | Photoperiodism | TAS | biological_process |
| GO:0032922 | Circadian regulation of gene expression | IEA ISS | biological_process |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IGI | biological_process |
| GO:0046983 | Protein dimerization activity | IEA | molecular_function |
| GO:0070888 | E-box binding | IDA | molecular_function |
| GO:0071479 | Cellular response to ionizing radiation | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9484172144 | 0.0906989932 | 0.9999902473 | 0.5724911751 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1324067954 |
| GSE13712_SHEAR | Up | 0.0627733885 |
| GSE13712_STATIC | Up | 0.1015420895 |
| GSE19018 | Down | -0.0992652056 |
| GSE19899_A1 | Down | -0.2746243281 |
| GSE19899_A2 | Down | -0.2533347952 |
| PubMed_21979375_A1 | Up | 0.2247430855 |
| PubMed_21979375_A2 | Down | -0.2350904956 |
| GSE35957 | Up | 0.0469733144 |
| GSE36640 | Down | -0.4051929154 |
| GSE54402 | Down | -0.1422685761 |
| GSE9593 | Down | -0.3842410348 |
| GSE43922 | Down | -0.0862313206 |
| GSE24585 | Down | -0.0483861312 |
| GSE37065 | Down | -0.1203511210 |
| GSE28863_A1 | Up | 0.3105862042 |
| GSE28863_A2 | Up | 0.4094274126 |
| GSE28863_A3 | Down | -0.2573066472 |
| GSE28863_A4 | Down | -0.3018863373 |
| GSE48662 | Down | -0.2437340175 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-141-3p | MIMAT0000432 | MIRT002951 | Luciferase reporter assay//Reporter assay | Functional MTI | 15131085 |
| hsa-miR-141-3p | MIMAT0000432 | MIRT002951 | Northern blot//qRT-PCR//Western blot | Functional MTI | 16762633 |
| hsa-miR-182-5p | MIMAT0000259 | MIRT005358 | Luciferase reporter assay//qRT-PCR | Functional MTI | 20656788 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT020471 | Microarray | Functional MTI (Weak) | 17242205 |
| hsa-miR-142-3p | MIMAT0000434 | MIRT021546 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028847 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030679 | Microarray | Functional MTI (Weak) | 18591254 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-141-3p | MIMAT0000432 | 1 | hsa-miR-141 | 15131085 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
