HCSGD entry for BCAR1

1. General information

Official gene symbol	BCAR1
Entrez ID	9564
Gene full name	breast cancer anti-estrogen resistance 1
Other gene symbols	CAS CAS1 CASS1 CRKAS P130Cas
Links to Entrez Gene	Links to Entrez Gene

2. Neighbors in the network

This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID	GO term	Evidence	Category
GO:0001558	Regulation of cell growth	TAS	biological_process
GO:0001726	Ruffle	IDA	cellular_component
GO:0004871	Signal transducer activity	TAS	molecular_function
GO:0005515	Protein binding	IPI	molecular_function
GO:0005737	Cytoplasm	IDA	cellular_component
GO:0005829	Cytosol	TAS	cellular_component
GO:0005886	Plasma membrane	IDA	cellular_component
GO:0005925	Focal adhesion	IDA ISS	cellular_component
GO:0007015	Actin filament organization	IDA	biological_process
GO:0007155	Cell adhesion	IEA	biological_process
GO:0007173	Epidermal growth factor receptor signaling pathway	ISS	biological_process
GO:0007186	G-protein coupled receptor signaling pathway	IEA ISS NAS	biological_process
GO:0007229	Integrin-mediated signaling pathway	IDA	biological_process
GO:0007596	Blood coagulation	TAS	biological_process
GO:0008283	Cell proliferation	TAS	biological_process
GO:0008286	Insulin receptor signaling pathway	ISS	biological_process
GO:0010595	Positive regulation of endothelial cell migration	IDA	biological_process
GO:0016477	Cell migration	IDA	biological_process
GO:0017124	SH3 domain binding	IEA	molecular_function
GO:0019901	Protein kinase binding	IPI	molecular_function
GO:0030027	Lamellipodium	IEA	cellular_component
GO:0030168	Platelet activation	TAS	biological_process
GO:0030335	Positive regulation of cell migration	IDA	biological_process
GO:0035729	Cellular response to hepatocyte growth factor stimulus	IMP	biological_process
GO:0042981	Regulation of apoptotic process	TAS	biological_process
GO:0048008	Platelet-derived growth factor receptor signaling pathway	IEA ISS	biological_process
GO:0048010	Vascular endothelial growth factor receptor signaling pathway	IMP	biological_process
GO:0048011	Neurotrophin TRK receptor signaling pathway	ISS	biological_process
GO:0048012	Hepatocyte growth factor receptor signaling pathway	IMP	biological_process
GO:0050851	Antigen receptor-mediated signaling pathway	IDA	biological_process
GO:0050852	T cell receptor signaling pathway	NAS	biological_process
GO:0050853	B cell receptor signaling pathway	IDA	biological_process
GO:0051301	Cell division	NAS	biological_process
GO:0060326	Cell chemotaxis	IMP	biological_process

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4. Expression levels in datasets

Meta-analysis result

p-value up	p-value down	FDR up	FDR down
0.7283635652	0.2479598989	0.9999902473	0.9578382008

Individual experiment result
( "-" represent NA in the specific microarray platform )

Data source	Up or down	Log fold change
GSE11954	Down	-0.1238835800
GSE13712_SHEAR	Up	0.5732204335
GSE13712_STATIC	Up	0.2588629370
GSE19018	Up	0.0037980018
GSE19899_A1	Down	-0.2916712174
GSE19899_A2	Up	0.2085481583
PubMed_21979375_A1	Down	-0.5119603060
PubMed_21979375_A2	Down	-0.1400762573
GSE35957	Down	-0.0763088951
GSE36640	Down	-0.0848897671
GSE54402	Down	-0.0049021994
GSE9593	Up	0.1911628762
GSE43922	Up	0.0100217684
GSE24585	Down	-0.2007013750
GSE37065	Down	-0.3201827149
GSE28863_A1	Down	-0.1075023857
GSE28863_A2	Down	-0.2229658720
GSE28863_A3	Up	0.3074088481
GSE28863_A4	Up	0.2026369168
GSE48662	Down	-0.0501678829

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Not regulated by compounds

Drugs

Not regulated by drugs

MicroRNAs

mirTarBase

No target information from mirTarBase

mirRecord

No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

1.General information
2.Neighbors in the network
3.Gene Ontology Annotation
4.Expression levels
5.Regulation
6.Text-mining results