HCSGD entry for PTGES
1. General information
| Official gene symbol | PTGES |
|---|---|
| Entrez ID | 9536 |
| Gene full name | prostaglandin E synthase |
| Other gene symbols | MGST-IV MGST1-L1 MGST1L1 MPGES PGES PIG12 PP102 PP1294 TP53I12 mPGES-1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001516 | Prostaglandin biosynthetic process | IDA | biological_process |
| GO:0002526 | Acute inflammatory response | IEA | biological_process |
| GO:0002544 | Chronic inflammatory response | IEA | biological_process |
| GO:0005641 | Nuclear envelope lumen | IEA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0006693 | Prostaglandin metabolic process | TAS | biological_process |
| GO:0007165 | Signal transduction | NAS | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | IEA | biological_process |
| GO:0014070 | Response to organic cyclic compound | IEA | biological_process |
| GO:0016020 | Membrane | TAS | cellular_component |
| GO:0016021 | Integral component of membrane | IDA | cellular_component |
| GO:0019369 | Arachidonic acid metabolic process | TAS | biological_process |
| GO:0019371 | Cyclooxygenase pathway | TAS | biological_process |
| GO:0032496 | Response to lipopolysaccharide | IEA | biological_process |
| GO:0032526 | Response to retinoic acid | IEA | biological_process |
| GO:0034097 | Response to cytokine | IEA | biological_process |
| GO:0043295 | Glutathione binding | IDA | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0050220 | Prostaglandin-E synthase activity | EXP IDA | molecular_function |
| GO:0051592 | Response to calcium ion | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3605032256 | 0.0784431481 | 0.9999902473 | 0.5298791635 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0096266745 |
| GSE13712_SHEAR | Up | 0.0046985019 |
| GSE13712_STATIC | Up | 0.0284298328 |
| GSE19018 | Down | -0.1908066743 |
| GSE19899_A1 | Down | -0.0580345973 |
| GSE19899_A2 | Down | -0.2903186113 |
| PubMed_21979375_A1 | Down | -0.0889676840 |
| PubMed_21979375_A2 | Down | -0.1745918822 |
| GSE35957 | Down | -0.8056896188 |
| GSE36640 | Down | -0.4500803728 |
| GSE54402 | Down | -0.7770697725 |
| GSE9593 | Down | -1.3747875494 |
| GSE43922 | Down | -0.2168096881 |
| GSE24585 | Up | 0.1799722887 |
| GSE37065 | Up | 0.9534582658 |
| GSE28863_A1 | Up | 0.2256173585 |
| GSE28863_A2 | Down | -0.1065602525 |
| GSE28863_A3 | Up | 0.6122775418 |
| GSE28863_A4 | Down | -0.0005259279 |
| GSE48662 | Up | 0.6524538635 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017384 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022404 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT046064 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23551866 | Expression of adrenomedullin (ADM), heat shock 70 kDa protein 8 (HSPA8) and prostaglandin E synthase (PGES) in OPEC was measured by quantitative polymerase chain reaction |
| 23551866 | We also demonstrated that spermatozoa-oviduct coculture for 12 and 24 h resulted in significantly higher expression of ADM, HSPA8 and PGES in OPEC |
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