HCSGD entry for BAG2
1. General information
| Official gene symbol | BAG2 |
|---|---|
| Entrez ID | 9532 |
| Gene full name | BCL2-associated athanogene 2 |
| Other gene symbols | BAG-2 dJ417I1.2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0006457 | Protein folding | TAS | biological_process |
| GO:0019538 | Protein metabolic process | IDA | biological_process |
| GO:0051087 | Chaperone binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9620139660 | 0.0009888416 | 0.9999902473 | 0.0595590389 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3003351354 |
| GSE13712_SHEAR | Up | 0.9372807497 |
| GSE13712_STATIC | Up | 0.7441446570 |
| GSE19018 | Down | -0.7598485226 |
| GSE19899_A1 | Down | -1.0382414531 |
| GSE19899_A2 | Down | -1.2798066805 |
| PubMed_21979375_A1 | Down | -0.9495223106 |
| PubMed_21979375_A2 | Down | -0.8837743014 |
| GSE35957 | Down | -0.3499709172 |
| GSE36640 | Down | -0.1292427890 |
| GSE54402 | Down | -1.2779524416 |
| GSE9593 | Down | -0.0806326402 |
| GSE43922 | Down | -0.9667954532 |
| GSE24585 | Down | -0.2576689787 |
| GSE37065 | Down | -0.0682060300 |
| GSE28863_A1 | Up | 0.2150741687 |
| GSE28863_A2 | Down | -0.1283413743 |
| GSE28863_A3 | Down | -1.1454267061 |
| GSE28863_A4 | Down | -0.4840934379 |
| GSE48662 | Down | -0.6451063244 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-128-3p | MIMAT0000424 | MIRT021988 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT025092 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT048797 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22146591 | BAG2 is a target of the c-Myc gene and is involved in cellular senescence via the p21(CIP1) pathway |
| 22146591 | A proteomics survey indicated that high levels of BCL2-associated athanogene 2 (BAG2) were found in response to c-Myc repression in TRE293 cells |
| 22146591 | This observation led to the investigation into the role of BAG2 in c-Myc-induced senescence |
| 22146591 | Furthermore, high levels of BAG2 were found to induce p21(CIP1)-dependent senescence and subsequent carcinogenetic arrest, suggesting its possible role as an indirect activator of the p21(CIP1) pathway |
| 20463968 | Additionally, we identified the chaperone protein BAG-2 in averting SirT3 targeting of p53 -mediated senescence |
| 20463968 | These studies identify a complex relationship between p53, SirT3, and chaperoning factor BAG-2 that may link the salvaging and quality assurance of the p53 protein for control of cellular fate independent of transcriptional activity |
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