HCSGD entry for CD38

1. General information

Official gene symbolCD38
Entrez ID952
Gene full nameCD38 molecule
Other gene symbolsT10
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001666Response to hypoxiaIEAbiological_process
GO:0003953NAD+ nucleosidase activityIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0007165Signal transductionNASbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationIEAbiological_process
GO:0007565Female pregnancyIEAbiological_process
GO:0009986Cell surfaceIEAcellular_component
GO:0016020MembraneTAScellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0016849Phosphorus-oxygen lyase activityIEAmolecular_function
GO:0030307Positive regulation of cell growthIEAbiological_process
GO:0030890Positive regulation of B cell proliferationIMPbiological_process
GO:0032024Positive regulation of insulin secretionIEAbiological_process
GO:0032355Response to estradiolIEAbiological_process
GO:0032526Response to retinoic acidIEAbiological_process
GO:0032570Response to progesteroneIEAbiological_process
GO:0033194Response to hydroperoxideIEAbiological_process
GO:0042493Response to drugIMPbiological_process
GO:0043066Negative regulation of apoptotic processIMPbiological_process
GO:0045779Negative regulation of bone resorptionIEAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIMPbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIMPbiological_process
GO:0045907Positive regulation of vasoconstrictionIEAbiological_process
GO:0050853B cell receptor signaling pathwayIMPbiological_process
GO:0060292Long term synaptic depressionIEAbiological_process
GO:0070555Response to interleukin-1IEAbiological_process
GO:0097190Apoptotic signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.53667913830.58629590440.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0468779362
GSE13712_SHEARDown-0.1559907294
GSE13712_STATICDown-0.1526052670
GSE19018Up0.0823429869
GSE19899_A1Up0.2176304395
GSE19899_A2Down-0.0030229640
PubMed_21979375_A1Down-0.1669715363
PubMed_21979375_A2Down-0.0779198831
GSE35957Down-0.0189410135
GSE36640Up0.0168018758
GSE54402Down-0.1138223905
GSE9593Down-0.0392908280
GSE43922Up0.0125365483
GSE24585Up0.0150216837
GSE37065Up1.3162256203
GSE28863_A1Down-0.0831412478
GSE28863_A2Up0.0301705663
GSE28863_A3Up0.1291034197
GSE28863_A4Up0.0924046891
GSE48662Up0.1053047364

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

DaratumumabDB09331 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018938MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25604328Immunosenescence was investigated by analysing CD57(+) CD28(-) levels, immune activation by analysing CD38(+) HLA-DR(+) levels, inflammation by analysing interleukin (IL)-6 levels, and microbial translocation by analysing lipopolysaccharide (LPS) and soluble CD14 (sCD14) levels
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