HCSGD entry for SPTLC2

1. General information

Official gene symbolSPTLC2
Entrez ID9517
Gene full nameserine palmitoyltransferase, long chain base subunit 2
Other gene symbolsHSN1C LCB2 LCB2A NSAN1C SPT2 hLCB2a
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004758Serine C-palmitoyltransferase activityIDAmolecular_function
GO:0005739MitochondrionIEAcellular_component
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0006665Sphingolipid metabolic processTASbiological_process
GO:0006686Sphingomyelin biosynthetic processIEAbiological_process
GO:0009058Biosynthetic processIEAbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0016740Transferase activityIEAmolecular_function
GO:0017059Serine C-palmitoyltransferase complexIDAcellular_component
GO:0030148Sphingolipid biosynthetic processTASbiological_process
GO:0030170Pyridoxal phosphate bindingIEAmolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046511Sphinganine biosynthetic processIEAbiological_process
GO:0046512Sphingosine biosynthetic processIEAbiological_process
GO:0046513Ceramide biosynthetic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.82671351010.05934363440.99999024730.4590140758

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1464050264
GSE13712_SHEARUp0.1876877040
GSE13712_STATICDown-0.1121621667
GSE19018Down-0.2794868020
GSE19899_A1Up0.0390190113
GSE19899_A2Down-0.1953701656
PubMed_21979375_A1Down-1.9170738430
PubMed_21979375_A2Down-0.6998915678
GSE35957Down-0.0372677242
GSE36640Down-0.3357957903
GSE54402Up0.2934966675
GSE9593Up0.2843685878
GSE43922Down-0.4039128662
GSE24585Up0.0447546046
GSE37065Up0.1418255785
GSE28863_A1Down-0.1298162761
GSE28863_A2Up0.0941741687
GSE28863_A3Down-0.7868922729
GSE28863_A4Up0.2513125738
GSE48662Up0.1305352959

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.