HCSGD entry for ADAMTS1
1. General information
| Official gene symbol | ADAMTS1 |
|---|---|
| Entrez ID | 9510 |
| Gene full name | ADAM metallopeptidase with thrombospondin type 1 motif, 1 |
| Other gene symbols | C3-C5 METH1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001542 | Ovulation from ovarian follicle | IEA | biological_process |
| GO:0001822 | Kidney development | IEA | biological_process |
| GO:0004222 | Metalloendopeptidase activity | IEA | molecular_function |
| GO:0005604 | Basement membrane | IEA | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0007229 | Integrin-mediated signaling pathway | TAS | biological_process |
| GO:0008201 | Heparin binding | IEA | molecular_function |
| GO:0008237 | Metallopeptidase activity | TAS | molecular_function |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0008285 | Negative regulation of cell proliferation | TAS | biological_process |
| GO:0031410 | Cytoplasmic vesicle | IEA | cellular_component |
| GO:0060347 | Heart trabecula formation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2494035599 | 0.0021246951 | 0.9380610317 | 0.0884875000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3962812159 |
| GSE13712_SHEAR | Down | -0.1794411298 |
| GSE13712_STATIC | Up | 1.4242764819 |
| GSE19018 | Down | -0.0348570311 |
| GSE19899_A1 | Down | -1.4856277718 |
| GSE19899_A2 | Down | -1.8169752643 |
| PubMed_21979375_A1 | Down | -0.6234102649 |
| PubMed_21979375_A2 | Down | -1.1030183432 |
| GSE35957 | Down | -0.0039898409 |
| GSE36640 | Up | 1.7838429641 |
| GSE54402 | Down | -1.6985438863 |
| GSE9593 | Up | 0.6501690018 |
| GSE43922 | Down | -0.6244393661 |
| GSE24585 | Down | -1.1285507104 |
| GSE37065 | Down | -0.5072328398 |
| GSE28863_A1 | Down | -0.3199456997 |
| GSE28863_A2 | Up | 0.3702955060 |
| GSE28863_A3 | Down | -0.1089432301 |
| GSE28863_A4 | Up | 0.4625497911 |
| GSE48662 | Down | -0.6916334309 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022469 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029236 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT036972 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040291 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049047 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-125b-5p | MIMAT0000423 | NA | hsa-miR-125b | 18056640 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
