HCSGD entry for KIF23
1. General information
| Official gene symbol | KIF23 |
|---|---|
| Entrez ID | 9493 |
| Gene full name | kinesin family member 23 |
| Other gene symbols | CHO1 KNSL5 MKLP-1 MKLP1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000022 | Mitotic spindle elongation | TAS | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0000910 | Cytokinesis | IMP | biological_process |
| GO:0003777 | Microtubule motor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0005819 | Spindle | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005871 | Kinesin complex | IEA | cellular_component |
| GO:0005874 | Microtubule | IEA | cellular_component |
| GO:0007018 | Microtubule-based movement | IEA TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008017 | Microtubule binding | IDA IEA | molecular_function |
| GO:0008152 | Metabolic process | TAS | biological_process |
| GO:0019886 | Antigen processing and presentation of exogenous peptide antigen via MHC class II | TAS | biological_process |
| GO:0030496 | Midbody | IDA | cellular_component |
| GO:0032467 | Positive regulation of cytokinesis | IMP | biological_process |
| GO:0045171 | Intercellular bridge | IEA | cellular_component |
| GO:0051256 | Spindle midzone assembly involved in mitosis | IMP | biological_process |
| GO:0072686 | Mitotic spindle | IDA | cellular_component |
| GO:0097149 | Centralspindlin complex | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9617242126 | 0.0001258083 | 0.9999902473 | 0.0200890909 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.2529253735 |
| GSE13712_SHEAR | Up | 0.0985285456 |
| GSE13712_STATIC | Down | -0.2417792439 |
| GSE19018 | Up | 0.0072584950 |
| GSE19899_A1 | Down | -0.8704455921 |
| GSE19899_A2 | Down | -2.5903368353 |
| PubMed_21979375_A1 | Down | -1.2837053404 |
| PubMed_21979375_A2 | Down | -2.7609642326 |
| GSE35957 | Down | -2.1203280500 |
| GSE36640 | Down | -2.5976236040 |
| GSE54402 | Down | -0.7268813699 |
| GSE9593 | Down | -0.8996720286 |
| GSE43922 | Down | -1.6281336789 |
| GSE24585 | Down | -0.1684085101 |
| GSE37065 | Down | -1.1529252643 |
| GSE28863_A1 | Down | -0.1434142698 |
| GSE28863_A2 | Up | 0.6521971047 |
| GSE28863_A3 | Down | -0.1402559970 |
| GSE28863_A4 | Up | 0.3622069050 |
| GSE48662 | Down | -1.8148152707 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-424-5p | MIMAT0001341 | MIRT000657 | Luciferase reporter assay | Functional MTI | 19956200 |
| hsa-miR-373-3p | MIMAT0000726 | MIRT002495 | Microarray//Microarray;Other | Functional MTI (Weak) | 15685193 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT020426 | Microarray | Functional MTI (Weak) | 17242205 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024496 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026716 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031809 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-25-3p | MIMAT0000081 | MIRT050321 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-373-3p | MIMAT0000726 | NA | hsa-miR-373 | 15685193 | |||
| hsa-miR-331-3p | MIMAT0000760 | NA | hsa-miR-331-3p | 19996289 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
