HCSGD entry for ROCK2
1. General information
| Official gene symbol | ROCK2 |
|---|---|
| Entrez ID | 9475 |
| Gene full name | Rho-associated, coiled-coil containing protein kinase 2 |
| Other gene symbols | ROCK-II |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000910 | Cytokinesis | NAS | biological_process |
| GO:0001843 | Neural tube closure | IEA | biological_process |
| GO:0004672 | Protein kinase activity | IEA | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IDA IEA | molecular_function |
| GO:0005198 | Structural molecule activity | NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0006939 | Smooth muscle contraction | TAS | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0008625 | Extrinsic apoptotic signaling pathway via death domain receptors | IEA | biological_process |
| GO:0010825 | Positive regulation of centrosome duplication | IEA | biological_process |
| GO:0016525 | Negative regulation of angiogenesis | IMP | biological_process |
| GO:0017048 | Rho GTPase binding | IEA | molecular_function |
| GO:0030036 | Actin cytoskeleton organization | IEA | biological_process |
| GO:0030155 | Regulation of cell adhesion | TAS | biological_process |
| GO:0031616 | Spindle pole centrosome | IEA | cellular_component |
| GO:0032956 | Regulation of actin cytoskeleton organization | TAS | biological_process |
| GO:0035556 | Intracellular signal transduction | IEA | biological_process |
| GO:0045616 | Regulation of keratinocyte differentiation | IMP | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0051298 | Centrosome duplication | IMP | biological_process |
| GO:0051492 | Regulation of stress fiber assembly | TAS | biological_process |
| GO:0051893 | Regulation of focal adhesion assembly | TAS | biological_process |
| GO:2000114 | Regulation of establishment of cell polarity | TAS | biological_process |
| GO:2000145 | Regulation of cell motility | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8829039550 | 0.0297850918 | 0.9999902473 | 0.3263813566 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1694247538 |
| GSE13712_SHEAR | Up | 0.2362538243 |
| GSE13712_STATIC | Up | 0.2181103446 |
| GSE19018 | Up | 0.0439300909 |
| GSE19899_A1 | Down | -0.5433175203 |
| GSE19899_A2 | Down | -0.7775357470 |
| PubMed_21979375_A1 | Down | -0.5901505119 |
| PubMed_21979375_A2 | Down | -0.7459829935 |
| GSE35957 | Up | 0.1893747580 |
| GSE36640 | Down | -0.3814836083 |
| GSE54402 | Down | -0.2914319294 |
| GSE9593 | Up | 0.1800694741 |
| GSE43922 | Down | -0.4359257162 |
| GSE24585 | Down | -0.6216352396 |
| GSE37065 | Down | -0.1594097611 |
| GSE28863_A1 | Up | 0.3718436903 |
| GSE28863_A2 | Up | 0.4086480644 |
| GSE28863_A3 | Down | -0.1265913276 |
| GSE28863_A4 | Down | -0.2354751050 |
| GSE48662 | Up | 0.0938492091 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE | DB08162 | - |
| (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE | DB08756 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-138-5p | MIMAT0000430 | MIRT000494 | qRT-PCR//Luciferase reporter assay//Western blot//Reporter assay;Other | Functional MTI | 20232393 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT006478 | Immunohistochemistry//Luciferase reporter assay//qRT-PCR//Western blot//Reporter assay;qRT-PCR | Functional MTI | 21672940 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-138-5p | MIMAT0000430 | 1 | hsa-miR-138 | {Western blot} | {overexpression by miRNA mimics tranfection} | 20232393 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26765561 | Here, we provide evidence that ROCK1 and ROCK2 act redundantly to maintain actomyosin contractility and cell proliferation and that their loss leads to cell-cycle arrest and cellular senescence |
| 26765561 | Accordingly, while the loss of either Rock1 or Rock2 had no negative impact on tumorigenesis in mouse models of non-small cell lung cancer and melanoma, loss of both blocked tumor formation, as no tumors arise in which both Rock1 and Rock2 have been genetically deleted |
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