HCSGD entry for ATG5

1. General information

Official gene symbolATG5
Entrez ID9474
Gene full nameautophagy related 5
Other gene symbolsAPG5 APG5-LIKE APG5L ASP hAPG5
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000045Autophagic vacuole assemblyISSbiological_process
GO:0001974Blood vessel remodelingIEAbiological_process
GO:0002739Regulation of cytokine secretion involved in immune responseIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmISScellular_component
GO:0005776Autophagic vacuoleIDAcellular_component
GO:0005930AxonemeISScellular_component
GO:0006914AutophagyISSbiological_process
GO:0006915Apoptotic processIEAbiological_process
GO:0009620Response to fungusIEAbiological_process
GO:0031397Negative regulation of protein ubiquitinationIEAbiological_process
GO:0032480Negative regulation of type I interferon productionTASbiological_process
GO:0034045Pre-autophagosomal structure membraneISScellular_component
GO:0042311VasodilationIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0043687Post-translational protein modificationISSbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0048840Otolith developmentIEAbiological_process
GO:0055015Ventricular cardiac muscle cell developmentIEAbiological_process
GO:0060047Heart contractionIEAbiological_process
GO:1902017Regulation of cilium assemblyISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.89932121120.10158071120.99999024730.6101565267

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2417337420
GSE13712_SHEARUp0.1674216156
GSE13712_STATICUp0.2398795654
GSE19018Down-0.0230344506
GSE19899_A1Down-0.3054864162
GSE19899_A2Down-0.9585108814
PubMed_21979375_A1Down-0.4659570116
PubMed_21979375_A2Down-1.1511662508
GSE35957Down-0.0061557951
GSE36640Down-0.4707071905
GSE54402Up0.1431112207
GSE9593Up0.0920024344
GSE43922Up0.0038978443
GSE24585Up0.1526549030
GSE37065Up0.0807432318
GSE28863_A1Down-0.1728339921
GSE28863_A2Up0.1988932511
GSE28863_A3Down-0.5568850792
GSE28863_A4Down-0.1781526310
GSE48662Down-0.2256329547

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 10 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26761120In our recent study we used mice with a selective deletion of Atg5 in the S3 proximal tubule segment, which is most susceptible to ischemic damage
26487561Compared with kidneys from control mice, kidneys from mice with conditional deletion of autophagy-related 5 (Atg5) for selective ablation of autophagy in proximal tubular S3 segments (Atg5(Delta) (flox/) (Delta) (flox)) presented with significantly less tubular senescence, reduced interstitial fibrosis, and superior renal function 30 days after ischemia/reperfusion injury
26159917Additionally, the cellular senescence phenotypes were manifested at the molecular level by a significant increase in p21 and p53 expression, a decrease in SOD2 expression, and a decrease in expression of some key autophagy-related genes such as Atg5, Atg7, Atg12, and Beclin 1
25341032Atg5(f/-);Aqp5-Cre mice with salivary acinar-specific knockout (KO) of autophagy essential gene Atg5 were generated
25341032Extended ligation period resulted in the caspase-3 activation and acinar cell death, which was delayed by Atg5 knockout
25341032The role of autophagy-related 5 (ATG5)-dependent autophagy in regulating the tempo, duration and magnitude of cellular stress responses in vivo was corroborated by in vitro studies using MEFs lacking ATG5 or autophagy-related 7 (ATG7) and autophagy inhibitors
25341032Collectively, our results highlight the role of ATG5 in the dynamic regulation of ligation-induced cellular senescence and apoptosis, and suggest the involvement of autophagy resolution in salivary repair
24367027Autophagy inhibition by knockdown of ATG5 and LC3B attenuated the antisenescent effect of SIRT6 overexpression
22898871Surprisingly, targeting autophagy by inhibiting ATG5 is accompanied by a strong SA-beta-Gal staining, suggesting a specific inhibitory role on senescence
22627293The inhibition of autophagy by a pharmacologic inhibitor or through RNAi-mediated depletion of the ATG5 gene enhanced the cytotoxic activity of Ant1,5, as revealed by the marked increase in drug-induced apoptosis
22613224Inhibition of autophagy, due to the diminished expression of ATG5 by RNAi decreased the number of senescent cells induced by curcumin, but did not lead to increased cell death
21816217Downregulation of autophagy protein 5 (Atg5) with Atg5 siRNA inhibited not only autophagy but also senescence induced by H2O2
21816217Further studies showed that Atg5 regulates H2O2-induced senescence primarily by up-regulating the expression of p21 at the level of post-transcription
21536669These trends were observed in SK-N-SH cells under serum or serum-free conditions and in WT or Atg5(-/-) mouse embryonic fibroblasts (MEFs)
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