HCSGD entry for EIF2AK3

1. General information

Official gene symbolEIF2AK3
Entrez ID9451
Gene full nameeukaryotic translation initiation factor 2-alpha kinase 3
Other gene symbolsPEK PERK WRS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001501Skeletal system developmentISSbiological_process
GO:0001503OssificationIMPbiological_process
GO:0002063Chondrocyte developmentIEA ISSbiological_process
GO:0004672Protein kinase activityTASmolecular_function
GO:0004674Protein serine/threonine kinase activityIEA ISS TASmolecular_function
GO:0004694Eukaryotic translation initiation factor 2alpha kinase activityIDA IMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005737CytoplasmISScellular_component
GO:0005783Endoplasmic reticulumIC ISS TAScellular_component
GO:0005789Endoplasmic reticulum membraneIEA ISS NAS TAScellular_component
GO:0006412TranslationIEAbiological_process
GO:0006468Protein phosphorylationISSbiological_process
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processIEA ISSbiological_process
GO:0006983ER overload responseIDAbiological_process
GO:0006987Activation of signaling protein activity involved in unfolded protein responseTASbiological_process
GO:0007029Endoplasmic reticulum organizationIEA ISSbiological_process
GO:0007595LactationIEAbiological_process
GO:0009967Positive regulation of signal transductionIEAbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0017148Negative regulation of translationTASbiological_process
GO:0019217Regulation of fatty acid metabolic processIEAbiological_process
GO:0019722Calcium-mediated signalingIEA ISSbiological_process
GO:0019903Protein phosphatase bindingIPImolecular_function
GO:0030073Insulin secretionISSbiological_process
GO:0030282Bone mineralizationIEA ISSbiological_process
GO:0030968Endoplasmic reticulum unfolded protein responseIDA IEA TASbiological_process
GO:0031016Pancreas developmentIEAbiological_process
GO:0031018Endocrine pancreas developmentIMPbiological_process
GO:0031642Negative regulation of myelinationIEA ISSbiological_process
GO:0032055Negative regulation of translation in response to stressIEAbiological_process
GO:0032057Negative regulation of translational initiation in response to stressTASbiological_process
GO:0032092Positive regulation of protein bindingIEAbiological_process
GO:0032933SREBP signaling pathwayIEAbiological_process
GO:0034976Response to endoplasmic reticulum stressIMPbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0045444Fat cell differentiationIEAbiological_process
GO:0046777Protein autophosphorylationIDA IEA IMPbiological_process
GO:0048009Insulin-like growth factor receptor signaling pathwayIEA ISSbiological_process
GO:0051260Protein homooligomerizationIMPbiological_process
GO:0070059Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.43519801680.55875125950.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0382540078
GSE13712_SHEARUp0.1486389222
GSE13712_STATICDown-0.0592615861
GSE19018Down-0.0679419723
GSE19899_A1Down-0.2640666316
GSE19899_A2Down-0.1639640259
PubMed_21979375_A1Down-0.0228579537
PubMed_21979375_A2Down-0.0475023466
GSE35957Up0.2886024307
GSE36640Up0.4185318722
GSE54402Down-0.0123560750
GSE9593Up0.0258344336
GSE43922Up0.2202871174
GSE24585Up0.0498441678
GSE37065Up0.2008855213
GSE28863_A1Up0.1057620231
GSE28863_A2Up0.4754472986
GSE28863_A3Down-0.1771464108
GSE28863_A4Down-0.1401800943
GSE48662Down-0.6002331305

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT019050MicroarrayFunctional MTI (Weak)18185580
hsa-miR-215-5pMIMAT0000272MIRT024874MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026817MicroarrayFunctional MTI (Weak)19074876
hsa-miR-26b-5pMIMAT0000083MIRT030259MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.