HCSGD entry for TP53INP1
1. General information
| Official gene symbol | TP53INP1 |
|---|---|
| Entrez ID | 94241 |
| Gene full name | tumor protein p53 inducible nuclear protein 1 |
| Other gene symbols | SIP TP53DINP1 TP53INP1A TP53INP1B Teap p53DINP1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005776 | Autophagic vacuole | IDA | cellular_component |
| GO:0005829 | Cytosol | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006914 | Autophagy | IEA | biological_process |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0006950 | Response to stress | TAS | biological_process |
| GO:0007050 | Cell cycle arrest | TAS | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | ISS | biological_process |
| GO:0009408 | Response to heat | IEA | biological_process |
| GO:0010508 | Positive regulation of autophagy | IMP | biological_process |
| GO:0016209 | Antioxidant activity | ISS | molecular_function |
| GO:0016605 | PML body | IEA | cellular_component |
| GO:0030336 | Negative regulation of cell migration | ISS | biological_process |
| GO:0031410 | Cytoplasmic vesicle | IEA | cellular_component |
| GO:0034644 | Cellular response to UV | IEA | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | IEA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0048102 | Autophagic cell death | IMP | biological_process |
| GO:0071361 | Cellular response to ethanol | IEA | biological_process |
| GO:0071447 | Cellular response to hydroperoxide | IEA | biological_process |
| GO:0072703 | Cellular response to methyl methanesulfonate | IEA | biological_process |
| GO:2001235 | Positive regulation of apoptotic signaling pathway | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0026925231 | 0.9906691463 | 0.1397828402 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3527108712 |
| GSE13712_SHEAR | Up | 0.0456124813 |
| GSE13712_STATIC | Down | -0.0460626245 |
| GSE19018 | Up | 0.3940070383 |
| GSE19899_A1 | Up | 0.5223539841 |
| GSE19899_A2 | Up | 0.2963992039 |
| PubMed_21979375_A1 | Up | 0.8997704948 |
| PubMed_21979375_A2 | Up | 0.5423456014 |
| GSE35957 | Up | 0.4607590264 |
| GSE36640 | Up | 2.4769935161 |
| GSE54402 | Down | -0.4503177732 |
| GSE9593 | Up | 0.1284373853 |
| GSE43922 | Up | 0.6255831808 |
| GSE24585 | Up | 1.2060179058 |
| GSE37065 | Up | 0.4551382970 |
| GSE28863_A1 | Up | 0.3163453465 |
| GSE28863_A2 | Up | 0.3205047150 |
| GSE28863_A3 | Down | -0.0714770037 |
| GSE28863_A4 | Up | 0.0037409269 |
| GSE48662 | Up | 0.3720214945 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-93-5p | MIMAT0000093 | MIRT000021 | Luciferase reporter assay//Western blot | Functional MTI | 18974142 |
| hsa-miR-130b-3p | MIMAT0000691 | MIRT000335 | Luciferase reporter assay//Western blot | Functional MTI | 18974142 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT003007 | Western blot//Luciferase reporter assay//Reporter assay | Functional MTI | 17911264 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT003007 | Microarray//qRT-PCR//Western blot | Functional MTI | 21093163 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT003007 | Reporter assay;Other | Functional MTI | 20584899 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT004996 | Microarray | Functional MTI (Weak) | 17891175 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017855 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022652 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-26a-5p | MIMAT0000082 | MIRT050097 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-129-5p | MIMAT0000242 | NA | hsa-miR-129-5p | 19487295 | |||
| hsa-miR-125b-5p | MIMAT0000423 | NA | hsa-miR-125b | 21935352 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20647331 | Coincident with these DNA damage markers, the level of p53 protein and genes transcriptionally activated by p53, such as p21, TP53INP1, and DDIT4, increased |
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