HCSGD entry for HAND1

1. General information

Official gene symbolHAND1
Entrez ID9421
Gene full nameheart and neural crest derivatives expressed 1
Other gene symbolsHxt Thing1 bHLHa27 eHand
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0001525AngiogenesisISSbiological_process
GO:0001707Mesoderm formationIEAbiological_process
GO:0001824Blastocyst developmentIEPbiological_process
GO:0001829Trophectodermal cell differentiationIEPbiological_process
GO:0001947Heart loopingISSbiological_process
GO:0003144Embryonic heart tube formationIEAbiological_process
GO:0003218Cardiac left ventricle formationIMPbiological_process
GO:0003219Cardiac right ventricle formationIMPbiological_process
GO:0003713Transcription coactivator activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmIEAcellular_component
GO:0005730NucleolusIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006366Transcription from RNA polymerase II promoterIDAbiological_process
GO:0007507Heart developmentISSbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0019899Enzyme bindingIEAmolecular_function
GO:0035050Embryonic heart tube developmentISSbiological_process
GO:0042475Odontogenesis of dentin-containing toothIEAbiological_process
GO:0042802Identical protein bindingISSmolecular_function
GO:0042803Protein homodimerization activityNASmolecular_function
GO:0043425BHLH transcription factor bindingIPImolecular_function
GO:0043433Negative regulation of sequence-specific DNA binding transcription factor activityIEAbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0055010Ventricular cardiac muscle tissue morphogenesisIMPbiological_process
GO:0060411Cardiac septum morphogenesisIMPbiological_process
GO:0060485Mesenchyme developmentIEAbiological_process
GO:0060536Cartilage morphogenesisIEAbiological_process
GO:0060707Trophoblast giant cell differentiationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.23657012650.91021708140.92043788621.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1017733062
GSE13712_SHEARDown-0.0790247321
GSE13712_STATICUp0.2223007253
GSE19018Up0.3011357263
GSE19899_A1Up0.2142429790
GSE19899_A2Up0.2200128127
PubMed_21979375_A1Up0.3877090440
PubMed_21979375_A2Down-0.0943667200
GSE35957Up0.0739672035
GSE36640Up0.0903362531
GSE54402Down-0.0238399795
GSE9593Up0.1172772120
GSE43922Up0.1731412738
GSE24585Up0.0207138031
GSE37065Down-0.1299710475
GSE28863_A1Down-0.2891927544
GSE28863_A2Up0.0698248530
GSE28863_A3Up0.1688111717
GSE28863_A4Up0.1001515850
GSE48662Down-0.0261886256

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-196a-5pMIMAT0000226MIRT026100SequencingFunctional MTI (Weak)20371350
hsa-let-7d-5pMIMAT0000065MIRT032179SequencingFunctional MTI (Weak)20371350
hsa-miR-877-5pMIMAT0004949MIRT037374CLASHFunctional MTI (Weak)23622248
hsa-let-7b-5pMIMAT0000063MIRT052125CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.